Russian Chemical Bulletin

, Volume 68, Issue 1, pp 181–185 | Cite as

Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin

  • S. A. GoncharovaEmail author
  • I. K. Yakushchenko
  • T. A. Raevskaya
  • T. N. Yakushchenko
  • N. P. Konovalova
Full Articles


Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N′-dimethylethylenediamine. These structural analogs of prodimin, a water insoluble anticancer drug, are soluble in water, which significantly expands methods for their administration into a body. The compounds obtained and prodimin (as a reference substance) were studied on P388 murine leukemia and some of its drug-resistant strains. The data obtained suggest a high efficacy of one synthesized compound against drug-resistant tumors.

Key words

prodimin water-soluble analogs anticancer compounds drug-resistant tumors chemotherapy 


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Copyright information

© Springer Science+Business Media, Inc. 2019

Authors and Affiliations

  • S. A. Goncharova
    • 1
    Email author
  • I. K. Yakushchenko
    • 1
  • T. A. Raevskaya
    • 1
  • T. N. Yakushchenko
    • 1
  • N. P. Konovalova
    • 1
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow RegionRussian Federation

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