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Russian Chemical Bulletin

, Volume 67, Issue 12, pp 2290–2296 | Cite as

Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid

  • O. G. Tereshchenko
  • E. D. Nikolskaya
  • O. A. ZhuninaEmail author
  • V. V. Zavarzina
  • N. G. Yabbarov
  • M. V. Fomicheva
  • E. V. Zubkov
  • M. B. Sokol
  • N. V. Gukasova
  • E. S. Severin
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Abstract

Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.

Key words

hepatoprotectors silybin ursodeoxycholic acid polymeric particles poly(lactic-co-glycolic acid) 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • O. G. Tereshchenko
    • 1
  • E. D. Nikolskaya
    • 1
  • O. A. Zhunina
    • 1
    Email author
  • V. V. Zavarzina
    • 2
  • N. G. Yabbarov
    • 1
  • M. V. Fomicheva
    • 1
  • E. V. Zubkov
    • 1
    • 3
  • M. B. Sokol
    • 1
  • N. V. Gukasova
    • 2
  • E. S. Severin
    • 1
  1. 1.Russian Research Center for Molecular Diagnostics and TherapyMoscowRussian Federation
  2. 2.National Research Center “Kurchatov Institute”MoscowRussian Federation
  3. 3.Sechenov University, Ministry of Health of the Russian FederationMoscowRussian Federation

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