Anion exchange kinetics with participation of cinchomeronic and dipicolinic acids
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The rate of sorption and desorption of cinchomeronic and dipicolinic acids on the AB-17-8 strongly basic anion exchanger is limited by slow diffusion of components in the polymer phase. The diffusion coefficient of the organic anion in the phase of the AB-17-8 anion exchanger is equal to (3.7±0.5)•10–12 m2 s–1. Taking into account high rates of desorption of anions of cinchomeronic and dipicolinic acids from anionite (the half-transformation time is 6 min), the AB-17-8 strongly basic anion exchanger can be recommended for use as a container for development of prolonged drugs based on pyridinedicarboxylic acids.
Key wordsstrongly basic anion exchanger pyridinedicarboxylic acids kinetics of sorption processes diffusion
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