Anion exchange kinetics with participation of cinchomeronic and dipicolinic acids
- 14 Downloads
The rate of sorption and desorption of cinchomeronic and dipicolinic acids on the AB-17-8 strongly basic anion exchanger is limited by slow diffusion of components in the polymer phase. The diffusion coefficient of the organic anion in the phase of the AB-17-8 anion exchanger is equal to (3.7±0.5)•10–12 m2 s–1. Taking into account high rates of desorption of anions of cinchomeronic and dipicolinic acids from anionite (the half-transformation time is 6 min), the AB-17-8 strongly basic anion exchanger can be recommended for use as a container for development of prolonged drugs based on pyridinedicarboxylic acids.
Key wordsstrongly basic anion exchanger pyridinedicarboxylic acids kinetics of sorption processes diffusion
Unable to display preview. Download preview PDF.
- 3.M. Chatterjee, M. Maji, S. Ghosh, T. C. W. Mak, J. Chem. Soc., Dalton Trans., 1998, 3641.Google Scholar
- 4.K. E. Smith, M. P. Callahan, P. A. Gerakines, J. P. Dworkin, C. H. House, Geochim. Cosmochim. Acta, 2014, 1,136.Google Scholar
- 5.M. D. Mashkovskiy, Lekarstvennye sredstva [Medicines], Novaya volna, Moscow, 2002, 1, 608 pp. (in Russian).Google Scholar
- 6.E. V. Ostapova, G. Yu. Shkurenko, S. Yu. Lyrschikov, H. N. Altshuler, Butlerov Commun., 2016, 48, No. 10,37.Google Scholar
- 11.O. N. Fedoseeva, E. P. Cherneva, N. N. Tunitskii, Russ. J. Phys. Chem., 1959,33.Google Scholar
- 12.The IUPAC Stability Constants Database; http://www.acadsoft.co.uk/scdbase/scdbase.htm.
- 13.J. Crank, The Mathematics of Diffusion, Clarendon Press, Oxford, 1975, 414 pp.Google Scholar