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Russian Chemical Bulletin

, Volume 67, Issue 4, pp 705–711 | Cite as

Xymedon conjugate with biogenic acids. Antioxidant properties of a conjugate of Xymedon with l-ascorbic acid

  • A. B. Vyshtakalyuk
  • V. E. Semenov
  • I. A. Sudakov
  • K. N. Bushmeleva
  • L. F. Gumarova
  • A. A. Parfenov
  • N. G. Nazarov
  • I. V. Galyametdinova
  • V. V. Zobov
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Abstract

Antiradical activity and antioxidant properties of a conjugate of Xymedon with l-ascorbic acid were studied. In contrast to Xymedon, a conjugate of Xymedon with l-ascorbic acid was found to react with free radicals. Pro-oxidant activity of the conjugate of Xymedon with l-ascorbic acid in a chemiluminescence system is weaker as compared to individual l-ascorbic acid. This is the evidence of the increase in the stability of ascorbic acid upon conjugation with a molecule of Xymedon. Conjugate of Xymedon with l-ascorbic acid facilitates the decrease in the concentration of a lipid peroxidation product (malondialdehyde) and the activity of superoxide dismutase in liver and serum of laboratory animals exposed to intoxication with a known hepatotropic toxin CCl4. This observation shows the contribution of the antioxidant action to the hepatoprotective effect of the studied Xymedon derivative.

Key words

pyrimidines antiradical activity toxic liver injury ascorbic acid antioxidant activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. B. Vyshtakalyuk
    • 1
  • V. E. Semenov
    • 1
    • 2
  • I. A. Sudakov
    • 2
  • K. N. Bushmeleva
    • 2
  • L. F. Gumarova
    • 1
  • A. A. Parfenov
    • 1
    • 2
  • N. G. Nazarov
    • 1
    • 3
  • I. V. Galyametdinova
    • 1
  • V. V. Zobov
    • 1
    • 3
  1. 1.A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific CenterRussian Academy of SciencesKazan, Russian FederationRussia
  2. 2.Kazan National Research Technological UniversityKazan, Russian FederationRussia
  3. 3.Kazan Federal UniversityKazan, Russian FederationRussia

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