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A simple, rapid and effective protocol for synthesis of bis(pyrazolyl)methanes using nickel–guanidine complex immobilized on MCM-41

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Abstract

In this paper, a rapid, easy and very efficient method for the synthesis of bis(pyrazolyl)methanes has been reported in the presence of nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni) as a recyclable nanocatalyst. This mesoporous silica catalyst was effective for the one-pot multi-component reaction of arylaldehydes, phenylhydrazine and ethyl acetoacetate in ethanol solvent. The current synthesis shows attractive features, for example the use of recoverable and reusable nanocatalyst (5 times), easy workup, suitable one-pot procedure, short reaction times, good to excellent yields and moderate reaction conditions.

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Acknowledgements

A. Kohzadian thanks IlamFarashimi Company for the support of this work. A. Zare and Z. Kordrostami thank the Research Council of Payame Noor University for supporting this work. H. Filian and A. Ghorbani-Choghamarani gratefully acknowledge the financial support through the start-up funds from the Islamic Azad University, Ahvaz and Ilam University, Iran, respectively.

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Correspondence to Alireza Kohzadian.

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Kohzadian, A., Filian, H., Kordrostami, Z. et al. A simple, rapid and effective protocol for synthesis of bis(pyrazolyl)methanes using nickel–guanidine complex immobilized on MCM-41. Res Chem Intermed 46, 1941–1953 (2020). https://doi.org/10.1007/s11164-019-04073-y

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Keywords

  • Nanocatalyst
  • Nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni)
  • Bis(pyrazolyl)methanes
  • Phenylhydrazine
  • Ethyl acetoacetate
  • Arylaldehyde