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Research on Chemical Intermediates

, Volume 45, Issue 11, pp 5399–5407 | Cite as

A combined pathway for the synthesis of nitidine family alkaloids

  • Gangaram Pallikonda
  • Chang-Yu Hsieh
  • Haw-Lih Su
  • Jen-Chieh HsiehEmail author
Article
  • 31 Downloads

Abstract

Three related alkaloids, oxynitidine, nitidine and 5,6-dihydronitidine, have been afforded by the new synthetic protocols. In this approach, the Ni-catalyzed annulation reaction is indicated as the key step to construct the isoquinolinone core structure. The subsequent transformations lead to the target alkaloids.

Keywords

Alkaloids Benzo[c]phenanthridine Nitidine Oxynitidine 5, 6-Dihydronitidine 

Notes

Acknowledgements

We thank the Ministry of Science and Technology of Taiwan (ROC) for the financial support of this research (MOST 107-2113-M-032-006) and the fellowship for Gangaram Pallikonda (MOST 107-2811-M-032-002).

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Gangaram Pallikonda
    • 1
  • Chang-Yu Hsieh
    • 1
  • Haw-Lih Su
    • 2
  • Jen-Chieh Hsieh
    • 1
    Email author
  1. 1.Department of ChemistryTamkang UniversityNew Taipei CityTaiwan, ROC
  2. 2.Central Laboratories UnitQatar UniversityDohaQatar

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