A novel chemosensor for Fe3+ based on open–closed-loop mechanism and imaging in living cells
In this paper, a novel chemosensor (named L1) for Fe3+ based on the rhodamine 6G and o-vanillin has been synthesized, which can selectively recognize Fe3+. The L1 solution showed a distinguishable colour change by naked eye, and the fluorescence turns on response after the addition of Fe3+. In addition, the experimental results showed that the spirocyclic of L1 was opened by cooperation between L1 and Fe3+, and then the fluorescence emission after excitation of the mixture solution was detected with the change in solution colour. The complexation coefficient of L1 towards Fe3+ was 1:1. Furthermore, L1 for Fe3+ sensing had a remarkable low detection limit of 427 nM (UV) and 130 nM (fluorescence), which is far below the drinking water standards (0.3 mg/L) of China. Meanwhile, the in vivo imaging and cell viability assay experiments demonstrated that L1 could be used for sensing Fe3+ in vivo.
KeywordsRhodamine 6G O-Vanillin Chemosensor Fluorescence Cell viability
This work was supported by key projects of Anhui Province University outstanding youth talent support program (gxyqZD2018078); Key Provincial Teaching and Research Projects in Anhui Province (2017jyxm0444); Innovation and Entrepreneurship Training Program for College Students (S201910375032).
- 4.C.T. Sempos, R.F. Gillum, A.C. Looker. Iron and Heart Disease. Preventive Nutrition (2005)Google Scholar
- 26.Department of Water Resources Management, Quality Standard for Ground Water of the National Standards of the People’s Republic of China, GB 5749-2006, Department of Water Resources Management, China, (2007)Google Scholar
- 27.Y. Gao, J. Wang, M. Fu, H.W. Chen, M.Z. Fang, J. Org. Chem. 37, 617 (2017)Google Scholar