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Synthesis of spiro-fused heterocycles under aerobic conditions by using polymer gel-entrapped catalyst

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Abstract

An expedient synthesis of spiro-fused heterocycles from multi-component reaction of urea, aryl aldehydes and Meldrum’s or barbituric acid by using polymer gel-entrapped catalyst under aerobic conditions at ambient temperature is reported. The developed protocol is simple, green, atom-economical and includes mild reaction conditions, does not involve tedious workup or purification procedure, avoids hazardous reagents/by-products and results in near-quantitative yields. The polymer gel-entrapped catalyst could be reused seven times without significant change in the catalytic activity.

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Acknowledgements

We gratefully acknowledge the Department of Chemistry, Shivaji University, Kolhapur, for providing research facility.

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Correspondence to Rajashri Salunkhe.

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Patil, A., Shinde, S., Rashinkar, G. et al. Synthesis of spiro-fused heterocycles under aerobic conditions by using polymer gel-entrapped catalyst. Res Chem Intermed 46, 63–73 (2020). https://doi.org/10.1007/s11164-019-03935-9

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Keywords

  • Aldehydes
  • Gel-entrapped ZnCl2
  • Modified Biginelli reaction
  • Spiro-fused heterocycles
  • Recyclability