Dendrimer-encapsulated copper(II) immobilized on Fe3O4@SiO2 NPs: a robust recoverable catalyst for click synthesis of 1,2,3-triazole derivatives in water under mild conditions

  • Ali Reza Sardarian
  • Fattah Mohammadi
  • Mohsen Esmaeilpour


In this paper, we have introduced Fe3O4@SiO2-dendrimer-encapsulated Cu(II) as a heterogeneous reusable catalyst for Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction in good to excellent yields at ambient temperature in water without requiring ligands, reducing agents and bases. This present methodology is a clean, and environmentally friendly approach that offers many advantages including excellent yields, operational simplicity, short reaction time, and absence of any tedious workup or purification. Moreover, of interesting features are the stability of the catalyst toward leaching and the possibility of catalyst recycling without any significant loss of activity.

Graphical abstract

In this paper, we have introduced Fe3O4@SiO2-dendrimer-encapsulated Cu(II) as a heterogeneous reusable catalyst for Cu-catalyzed azide-alkyne cycloaddition reaction (CuAAC) in good to excellent yields at ambient temperature in water without requiring ligands, reducing agents and bases.


Click reaction Multicomponent reaction Triazole Water Magnetic dendrimer catalyst 



The authors are grateful to the council of the Iran National Science Foundation and Shiraz University for their partially financial support to undertake this work.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Chemistry, College of SciencesShiraz UniversityShirazIran

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