Research on Chemical Intermediates

, Volume 45, Issue 2, pp 425–435 | Cite as

Spectrochemical and theoretical approaches for acylhydrazone-based fluoride sensors

  • Jemini Jose
  • A. Sreekanth
  • Athira M. John
  • Sabeel M. Basheer
  • P. B. SreejaEmail author


Acylhydrazone derivatives N′-[1-(2-fluorophenyl)ethylidene]pyridine-3-carbohydrazide (R1) and N′-[2-fluorobenzylidene]benzohydrazide (R2) were synthesized from their corresponding hydrazides and characterized by spectroscopic methods. The response of these acylhydrazones towards different anions was studied by colorimetric and spectrofluorometric methods in acetonitrile. The receptors exhibited a specific response towards fluoride ion. The binding affinity of the receptors with fluoride anion was studied by fluorescence spectroscopic techniques and ab initio density functional theory calculations with Becker’s three-parameter Lee–Yang–Par (B3LYP) exchange functional with 6-311G basis set.

Graphical abstract


Acylhydrazones TD-DFT Ab initio Fluoride sensing Anion recognition 



P.B.S. is grateful for financial support from CHRIST (Deemed to be University), Bengaluru.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of ChemistryCHRIST (Deemed to be University)BangaloreIndia
  2. 2.Department of ChemistryNational Institute of TechnologyTiruchirappalliIndia

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