Research on Chemical Intermediates

, Volume 44, Issue 10, pp 5801–5815 | Cite as

Sulfonated chitosan-encapsulated HAp@Fe3O4: an efficient and recyclable magnetic nanocatalyst for rapid eco-friendly synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4, 5]imidazo[1,2-a]pyrimidine-3-carbonitriles

  • Vilas N. Mahire
  • Girish P. Patil
  • Amol B. Deore
  • Padmakar G. Chavan
  • Harishchandra D. Jirimali
  • Pramod P. Mahulikar


A one-pot, multi-component, synthetic method for preparation of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles has been developed. It was accomplished by mixing 2-aminobenzimidazole, aldehyde and malononitrile in the presence of S-Chit-HAp@Fe3O4 as a nanocatalyst in aqueous medium. The catalyst (S-Chit-HAp@Fe3O4) was synthesized using a co-precipitation method and further characterized by using FT-IR, XRD, FE-SEM, EDX, HR-TEM, TGA and VSM analysis. It was found that the catalyst exhibits magnetic properties and showed high catalytical activity for the synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles.

Graphical Abstract

S-Chit-HAp@Fe3O4 nanoparticles catalyzing one-pot, multi-component synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles in aqueous medium has been reported herein.


Green chemistry S-Chit-HAp@Fe3O4 Chitosan Hydroxyapatite Fe3O4 nanoparticles 2-Aminobenzimidazole Malononitrile 



The authors are thankful to UGC, New Delhi, for financial assistance under a one-time grant [F. no. 19-110/2013 (BSR)] and major research project [F. no. 41-302/2012 (SR)]. the authors are also thankful to SAIF, IIT Bombay, IIT Madras and Panjab University, Chandigarh, for providing instrument facilities. Author VNM is very much grateful to the UGC, New Delhi, for awarding the Rajiv Gandhi National Fellowship.

Supplementary material

11164_2018_3456_MOESM1_ESM.doc (7.3 mb)
Supplementary material 1 (DOC 7467 kb)


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Vilas N. Mahire
    • 1
    • 2
  • Girish P. Patil
    • 3
    • 4
  • Amol B. Deore
    • 3
  • Padmakar G. Chavan
    • 3
  • Harishchandra D. Jirimali
    • 1
  • Pramod P. Mahulikar
    • 1
  1. 1.School of Chemical SciencesNorth Maharashtra UniversityJalgaonIndia
  2. 2.Department of ChemistryBhusawal Arts, Science and P. O. Nahata Commerce CollegeBhusawalIndia
  3. 3.School of Physical SciencesNorth Maharashtra UniversityJalgaonIndia
  4. 4.SVKM’s Institute of TechnologyDhuleIndia

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