Synthesis of some new pyrrolyl dipyrazoles and pyrrolyl pyrazolyl isoxazoles and biological evaluation as antioxidants

  • Ummadi Nagarjuna
  • Tamatam Rekha
  • Thata Sreenivasulu
  • Venkatapuram Padmavathi
  • Adivireddy Padmaja
Article
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Abstract

Some new systems of tris-heterocyclic pyrrolyl dipyrazoles (5) and pyrrolyl pyrazolyl isoxazoles (7) were prepared from the Michael acceptor E-1-(4-aryl-1H-pyrazol-3-yl)-3-(1H-pyrrol-2-yl)prop-2-en-1-one (3) using conventional and ultrasonication methods. All compounds were obtained in higher yield and shorter reaction time when using the ultrasound irradiation method compared with the conventional method. The title compounds were assayed for their antioxidant activity. Amongst all the tested compounds, 5c and 7c exhibited pronounced antioxidant activity compared with the standard drug.

Keywords

Pyrrole Pyrazole Isoxazole Cyclocondensation Antioxidant activity 

Notes

Acknowledgements

The authors are grateful to the University Grants Commission (UGC), New Delhi for the sanction of UGC-BSR fellowship. The authors are also grateful to Prof. Ch. Appa Rao, Department of Bio-chemistry (SVU), for providing facilities to carry out the antioxidant activity evaluation.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Ummadi Nagarjuna
    • 1
  • Tamatam Rekha
    • 1
  • Thata Sreenivasulu
    • 1
  • Venkatapuram Padmavathi
    • 1
  • Adivireddy Padmaja
    • 1
  1. 1.Department of ChemistrySri Venkateswara UniversityTirupatiIndia

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