Recent advances in microbial production of malic acid from renewable byproducts
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In the last few years, ecofriendly malic acid production has received a potential platform for the bio-based chemicals to replace the dependency of fossil based resources. The main goal of this paper is to explore the feasibility of efficient production of malic acid from cost effective alternative renewable byproducts as feedstock. To replace the traditional method of malic acid production from petroleum-based compounds such as maleic acid, the efficiency of fermentation technology for malic acid production using various microorganisms has been improved. To date, glucose is designated as the best substrate for malic acid production. However, few reviews concerning about malic acid production by employing various microbial strains were reported. The current knowledge on the biosynthesis of malic acid has assisted to improve malic acid production using various microbial strains. But, there is still need for the continuous production and replacement of low-cost substrates to increase the yield of malic acid. This review provides an overview about progress, achievements, merits, challenges and future perspectives in malic acid production from cost effective alternative substrates. Thus, malic acid production can be economical using renewable byproducts like crude glycerol by employing appropriate microorganism.
KeywordsMalic acid Techno-economic analysis Renewable waste Low-cost substrate Aspergillus species
The authors thank Science and Engineering Research Board (SERB), Department of Science and Technology, India for granting financial support (No. EEQ/2017/000200) for this work.
- Bharathiraja B, Chakravarthy M, Ranjith Kumar R, Yuvaraj D, Jayamuthunagai J, Praveen Kumar R, Palani S (2014) Biodiesel production using chemical and biological methods—a review of process, catalyst, acyl acceptor, source and process variables. Renew Sust Energy Rev 38:368–382CrossRefGoogle Scholar
- Blank LM, Weierckr N, Zambanini T, Sarikaya E, Buescher J, Meurer M (2018) Process for the production of malate. US20180265903A1Google Scholar
- Gadagi RS, Shin WS, Sa TM (2007) Malic acid mediated aluminum phosphate solubilization by Penicillium oxalicum CBPS-3F-Tsa isolated from Korean paddy rhizosphere soil. Dev Plant Soil Sci 102:285–290Google Scholar
- Oswald F, Dorsam S, Veith N, Zwick M, Neumann A, Ochsenreither K, Syldatk C (2016) Sequential mixed cultures: from syngas to malic acid. Front Microbiol 7:891Google Scholar
- Shigeo A, Akira F, Ichiro TK (1962) Method of producing l-malic acid by fermentation. US Patent 3,063,910Google Scholar
- Vivek N, Sindhu R, Madhavan A, Anju AJ, Castro E, Faraco V, Pandey A, Binod P (2017) Recent advances in the production of value added chemicals and lipids utilizing biodiesel industry generated crude glycerol as a substrate—metabolic aspects, challenges and possibilities: an overview. Bioresour Technol 239:507–517CrossRefGoogle Scholar
- Wang J, Lin M, Xu M, Yang ST (2016) Anaerobic fermentation for production of carboxylic acids as bulk chemicals from renewable biomass. Anaerob Biotechnol 156:323–361Google Scholar
- Werpy T, Petersen G (2004) Top value added chemicals from biomass. Vol. 1. Results of screening for potential candidates from sugars and synthesis gas. US Department of Energy (USDOE)Google Scholar
- Zelle RM, de Hulster E, van Winden WA, de Waard P, Dijkema C, Winkler AA, Geertman JMA, van Dijken JP, Pronk JT, van Maris AJA (2008) Malic acid production by Saccharomyces cerevisiae: engineering of pyruvate carboxylation, oxaloacetate reduction, and malate export. Appl Environ Microbiol 74(9):2766–2777CrossRefGoogle Scholar