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Role of eating disorders-related polymorphisms in obesity pathophysiology

  • Carolina Ferreira Nicoletti
  • Heitor Bernardes Pereira Delfino
  • Flávia Campos Ferreira
  • Marcela Augusta de Souza Pinhel
  • Carla Barbosa NoninoEmail author
Article
  • 154 Downloads

Abstract

Human biological system provides innumerable neuroendocrine inputs for food intake control, with effects on appetite’s modulation and the satiety signs. Its regulation is very complex, engaging several molecular interactions with many tissues, hormones, and neural circuits. Thus, signaling molecules that control food intake are critical for normal energy homeostasis and a deregulation of these pathways can lead to eating disorders and obesity. In line of this, genetic factors have a significantly influence of the regulation of neural circuits controlling the appetite and satiety pathways, as well as the regulation of brain reward systems. Single Nucleotide Polymorphisms (SNPs) in genes related to hypothalamic appetite and satiety mechanisms, further in multiple neurotransmitter systems may contribute to the development of major Eating Disorders (EDs) related to obesity, among them Binge Eating Disorder (BED) and Bulimia Nervosa (BN), which are discussed in this review.

Keywords

Obesity Food intake Eating disorders Binge eating disorder (BED) Bulimia nervosa (BN) Polymorphism 

Abbreviations

SNP

Single Nucleotide Polymorphisms

ED

Eating Disorders

BED

Binge Eating Disorder

BN

Bulimia Nervosa

MC4R

Melanocortin 4 receptor

OPRD1

Opioid Receptor delta 1

BDNF

Brain derived neurotropic factor

FTO

Fat mass and obesity associated

VTA

ventral tegmental area VTA

NAc

nucleus accumbens

PYY

peptide tyrosine tyrosine

CCK

cholecystokinin

ARC

arcuate nucleus

PVN

paraventricular nucleus

DMN

dorsomedial nucleus

VMN

ventromedial nucleus

LHA

lateral hypothalamic area

NPY

neuropeptide Y

AgRP

agouti related peptide

POMC

pro-opiomelanocortin

CART

cocaine- and amphetamine-regulated transcript

α-MSH

α-melanocyte-stimulating hormone

MC-Rs

G protein coupled melanocortin receptors

CRH

corticotropin-releasing hormone

TRH

thyrotropin-releasing hormone

CSF

lumbar cerebrospinal fluid

DSR

dopamine 2 receptors

DAT

dopamine transporter genes

DRD2

dopamine receptor gene

5-HTTLPR

serotonin transporter gene

BDNF

brain derived neurotrophic factor

ESR1

estrogen receptor 1

ESR2

estrogen receptor 2

CB1

cannabinoid receptor 1

DAT

dopamine transporter

COMT

catechol-O-methyltransferase

Notes

Acknowledgments

This study was supported by Coordination of Improvement of Higher Education Personnel (CAPES), Brazil.

Compliance with ethical standards

Conflicts of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Carolina Ferreira Nicoletti
    • 1
  • Heitor Bernardes Pereira Delfino
    • 1
  • Flávia Campos Ferreira
    • 1
  • Marcela Augusta de Souza Pinhel
    • 1
    • 2
  • Carla Barbosa Nonino
    • 3
    Email author
  1. 1.Department of Internal Medicine, Ribeirao Preto Medical SchoolUniversity of São PauloRibeirão PretoBrazil
  2. 2.Laboratory of Studies in Biochemistry and Molecular Biology, Department of Molecular BiologySão José do Rio Preto Medical SchoolSão PauloBrazil
  3. 3.Department of Health Sciences, Ribeirão Preto Medical School – FMRP/USP – Laboratory of Nutrigenomic StudiesUniversity of São PauloRibeirão PretoBrazil

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