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Associations between atherosclerosis and neurological diseases, beyond ischemia-induced cerebral damage

  • Dannia Colín-CastelánEmail author
  • Silvio Zaina
Article
  • 243 Downloads

Abstract

Neurodegeneration is traditionally viewed as a consequence of peptide accumulation in the brain, stroke and/or cerebral ischemia. Nonetheless, a number of scattered observations suggest that neurological disease and atherosclerosis may be linked by more complex mechanisms. Understanding the intricate link between atherosclerosis and neurological conditions may have a significant impact on the quality of life of the growing ageing population and of high cardiovascular risk groups in general. Epidemiological data support the notion that neurological dysfunction and atherosclerosis coexist long before any evident clinical complications of cardiovascular disease appear and may be causally linked. Baffling, often overlooked, molecular data suggest that nervous tissue-specific gene expression is relaxed specifically in the atheromatous vascular wall, and/or that a systemic dysregulation of genes involved in nervous system biology dictates a concomitant progression of neurological disease and atherosclerosis. Further epidemiological and experimental work is needed to clarify the details and clinical relevance of those complex links.

Keywords

Atherosclerosis Neurodegeneration Ischemia Gene expression Endothelial dysfunction 

Notes

Acknowledgments

D. Colín-Castelán was supported by a Consejo Nacional de Ciencia y Tecnología (CONACyT, Mexico) Postdoctoral Fellowship no. 2018-000005-01NACV-00163, within the “Estancias Posdoctorales Vinculadas al Fortalecimiento de la Calidad del Posgrado Nacional” program.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medical Sciences, Division of Health Sciences, Campus LeónUniversity of GuanajuatoLeónMexico

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