A novel sulfamic acid functionalized nano-catalyst on the basis of calixresorcinarene for the green one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under thermal solvent-free conditions
N-propyl sulfamic acid supported nano-catalyst on the basis of calixresorcinarene was prepared via the efficient and facile reaction of amine functionalized polycalixresorcinarene with chlorosulfonic acid. The achieved catalytic system was characterized using some spectroscopic techniques such as Fourier transform Infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and CHNS elemental analysis. This newly developed acidic catalyst was employed efficiently in a one-pot three-component condensation reaction of aromatic aldehydes, dimedone and phthalhydrazide for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives through an easy and eco-friendly methodology. The catalyst was easily separated from the reaction mixture by simple filtration and the desired products were achieved in good to excellent yields in short reaction times.
KeywordsN-propyl sulfamic acid functionalized nano-catalyst Heterogeneous catalysis Multi-component reactions Solvent-free One-pot condensation 2H-indazolo[2,1-b]phthalazine-triones
This work was supported by the Research Council at the University of Shahid Chamran.
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