Orthostatic hypotension and health-related quality of life among community-living older people in Korea
To investigate the association of orthostatic hypotension (OH) with health-related quality of life (HRQoL) in older people living in the community.
A cross-sectional design was used. A total of 217 participants aged 65 and older were classified as having OH if their systolic or diastolic blood pressure showed a drop of ≥ 20 mmHg systolic blood pressure or ≥ 10 mmHg diastolic blood pressure, respectively, within 3 min of standing. Participants provided demographic and medical information and responded to questionnaires about their HRQoL (EuroQoL-5D-3L), as well as depression, anxiety, cognitive function, and recent physical activities.
The number of participants with OH was 117, and those without OH numbered 100. The mean HRQoL levels were 0.56 (SD 0.29) in the OH group and 0.74 (SD 0.25) in the non-OH group (p < .001). Participants with OH were more likely to be older, women, and smokers. These participants had fewer years of education, a greater history of stroke and hypertension, and a greater number of comorbidities. The absence of OH, a higher physical activity level, a lower degree of depression, an absence of stroke history, and younger age were all significant determinants of greater HRQoL.
The level of HRQoL of older people with OH was significantly lower than that of older people without. The presence of OH was an independent determinant of HRQoL in older adults after adjusting for covariates. This finding suggests that strategies for relieving OH could improve HRQoL in affected older adults.
KeywordsCommunity Older adults Orthostatic hypotension Quality of life
The authors are grateful to Mr. Jon Mann for his editorial assistance during manuscript preparation.
NK contributed to the study conception and design, interpretation of data, drafting of the article, critical revision for scientific content, and final approval. JP and HH were involved in data acquisition, analysis, and interpretation. IDK was involved in acquisition and interpretation of data and critical revision for scientific content. HK contributed to analysis and interpretation of data, drafting of the article, and critical revision for scientific content.
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1D1A3B03934143).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional ethic committee (Institutional Review Board of Keimyung University, reference number 40525-201609-HR-92-01) and with 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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