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Quality of Life Research

, Volume 28, Issue 11, pp 2871–2887 | Cite as

Patient-reported outcomes as predictors of survival in patients with bowel cancer: a systematic review

  • Claudia RutherfordEmail author
  • Rachel Campbell
  • Kate White
  • Madeleine King
Article

Abstract

Introduction

The prognostic value of patient-reported outcomes (PROs) has been determined in some cancers, but a focussed review in colorectal cancer (CRC) has not yet been conducted. We systematically reviewed PRO predictors of CRC patient survival.

Methods

We searched four electronic databases (from inception to May 2018), reference lists and professional organisations to identify studies reporting pre-treatment PRO predictors of overall survival (OS) or progression-free survival (PFS) in CRC identified through univariate or multivariate models. Two reviewers independently applied inclusion criteria and extracted data on study characteristics, median and 1-year survival rates, PROs assessed and model results.

Results

In 25 of 27 studies (n = 12,544), at least one PRO was significantly associated with survival. Physical functioning, fatigue, pain and appetite loss predicted OS more often than other PROs in metastatic disease (19/27 studies). One study explored PRO predictors in early-stage CRC, finding emotional well-being and mood predicted OS. In mixed-stage samples (7/27 studies), physical functioning predicted OS more often than other PROs. Few studies modelled PFS, for which few PROs had predictive value.

Conclusions

Physical and psychological functioning, pain, fatigue and appetite loss had prognostic significance above and beyond clinical predictors in CRC. Routine monitoring of these PROs may allow earlier detection and amelioration of problems, which may improve quality of life and perhaps extend survival. More research is needed to determine prognostic value of PROs in early-stage CRC, and prognostic significance of changes in PRO scores.

Keywords

Bowel cancer Systematic review Patient-reported outcomes Survival Predictors 

Notes

Author contributions

CR conception of the study and led the design, analysis plan, data interpretation and manuscript writing. RC conducted the data extraction and contributed to results interpretation and writing of the manuscript. KW contributed to study conception, design considerations, results interpretation and revision of the manuscript. MK contributed to study conception, study design, resolved data extraction queries, data interpretation and revision of the manuscript. All authors read and approved the final manuscript.

Funding

This project has been supported by the generous contributions of the Estate of the Late Emma Elwin (Ellie) a’Beckett.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval and Informed consent

Ethics approval and consent to participate was not required for this secondary analysis.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Faculty of Science, School of Psychology, Quality of Life OfficeThe University of SydneySydneyAustralia
  2. 2.Faculty of Medicine and Health, The University of Sydney Susan Wakil School of Nursing and Midwifery, Cancer Nursing Research Unit (CNRU)The University of SydneySydneyAustralia

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