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Modality transition on renal replacement therapy and quality of life of patients: a 10-year follow-up cohort study

  • Daniela Cristina Sampaio de BritoEmail author
  • Elaine Leandro Machado
  • Ilka Afonso Reis
  • Daniela Pena Moreira
  • Thiago Henrique Mascarenhas Nébias
  • Mariângela Leal CherchigliaEmail author
Article

Abstract

Purpose

Despite advance in renal replacement therapy (RRT), patients with chronic end-stage renal disease (ESRD) face various limitations, and renal transplantation (Tx) is the treatment that impacts most on quality of life (QoL). This study aimed to assess changes in QoL in a cohort of ESRD dialysis patients.

Methods

Sociodemographic, clinical, nutritional, lifestyle, and QoL data were collected from 712 patients at baseline (time 1) and after 10 years of follow-up (time 2) for patients surviving. The QoL was assessed through the 36-Item Short Form Health Survey (SF-36) and the multiple linear regression model was used to analyze the factors associated with change in QoL.

Results

A total of 205 survivors were assessed and distributed into three groups according to current RRT (Dialysis–Dialysis, Dialysis–Tx, and Dialysis–Tx–Dialysis). At time 1, only age was significantly different among groups; at time 2, transplant patients sustained greater social participation, job retention, and improvement in SF-36 scores. The factors associated with change in QoL were more time on dialysis interfering negatively on physical functioning (p = 0.002), role-physical limitations (p  = 0.002), general health (p  = 0.007), social functioning (p = 0.02), role-emotional (p = 0.003), and physical components ( p = 0.002); non-participation in social groups at times 1 and 2 reducing vitality (p = 0.02) scores; and having work at time 2, increasing vitality (p = 0.02) and mental health (p  = 0.02) scores.

Conclusions

QoL was shown to be dynamic throughout the years of RRT, transplantation being the treatment with more benefits to the ESRD. More time on dialysis and limited social and occupational routine were associated with a reduction in QoL.

Keywords

Quality of life End-stage renal disease Chronic kidney disease Renal replacement therapy 

Notes

Acknowledgements

MLC was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council of Technological and Scientific Development), Brazil, and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (The Minas Gerais State Research Foundation), Brazil.

Author Contributions

Study conception and design: DCSB, MLC, ELM, IAR; data collection: DCSB, ELM, DPM, THMN, MLC; data analysis and interpretation: DCSB, ELM, DPM, THMN, MLC; statistical analysis: DCSB, ELM, IAR, DPM, MLC; supervision or mentoring: ELM, IAR, MLC. All authors contributed significant intellectual content during the preparation and revision of this manuscript and take full responsibility for the overall work, ensuring proper investigation and clarification of issues regarding the accuracy or integrity of any part of this work.

Funding

This study was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq [National Council of Technological and Scientific Development], Brazil (http://www.cnpq.br/web/guest/geral), Grant Number: 307054/2014-4, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (Capes) - Finance code 001 and Fundação de Amparo à Pesquisa do Estado de Minas Gerais – FAPEMIG [The Minas Gerais State Research Foundation], Brazil (http://www.fapemig.br/); Grant Number: (CDS-PPM-00716-15).

Compliance with ethical standards

Conflict of interest

DCSB, ELM, IAR, DPM, THMN, MLC declares that she has no conflict of interest. All authors have no other relevant financial interests to declare.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Review Board (IRB) at the Federal University of Minas Gerais—UFMG, approved the study (decision 397/2006 and 59817316.7.0000.5149/2016) and informed consent was obtained from all individual participants included in the study. This article does not contain any studies with animals performed by any of the authors.

Supplementary material

11136_2019_2113_MOESM1_ESM.pdf (697 kb)
Supplementary material 1 (PDF 697 KB)
11136_2019_2113_MOESM2_ESM.pdf (692 kb)
Supplementary material 2 (PDF 691 KB)

References

  1. 1.
    Tonelli, M., Wiebe, N., Knoll, G., Bello, A., Brown, S., Jadhav, D., et al. (2011). Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes. American Journal of Transplantation, 11(10), 2093–2109.CrossRefGoogle Scholar
  2. 2.
    Álvares, J., Cesar, C. C., Acurcio, F. A., Andrade, E. I., & Cherchiglia, M. L. (2012). Quality of life of patients in renal replacement therapy in Brazil: comparison of treatment modalitie. Quality of Life Research, 21(6), 983–991.CrossRefGoogle Scholar
  3. 3.
    Finkelstein, F. O., Wuerth, D., & Finkelstein, S. H. (2009). Health related quality of life and the CKD patient: Challenges for the nephrology community. Kidney International, 76(9), 946–952.CrossRefGoogle Scholar
  4. 4.
    Mucsi, I., Kovacs, A. Z., Molnar, M. Z., & Novak, M. (2008). Co-morbidity and quality of life in chronic kidney disease patients. Journal of Nephrology, 21(suppl13), S84–S91.Google Scholar
  5. 5.
    Valderrabano, F., Jofre, R., & Lopez-Gomez, J. M. (2001). Quality of life in end-stage renal disease patients. American Journal of Kidney Diseases, 38(3), 443–464.CrossRefGoogle Scholar
  6. 6.
    Evans, R. W., Manninen, D. L., Junior, G., Hart, L. P., Blagg, L. G., Gutman, C. R., R. A., et al (1985). The quality of life of patients with end-stage renal disease. New England Journal of Medicine, 312(9), 553–559.CrossRefGoogle Scholar
  7. 7.
    Mazairac, A. H. A., de Wit, G. A., Penne, E. L., van der Weerd, N. C., de Jong, B., Grooteman, M. P. C., et al. (2011). Changes in quality of life over time—Dutch haemodialysis patients and general population compared. Nephrology Dialysis Transplantation, 26(6), 1984–1989.CrossRefGoogle Scholar
  8. 8.
    Von Der Lippe, D., Waldum, B., Brekke, F. B., Amro, A. A., Reisaeter, A. V., & Os, I. (2014). From dialysis to transplantation: A 5-year longitudinal study on self-reported quality of life. BMC Nephrology, 15, 1–9.CrossRefGoogle Scholar
  9. 9.
    Hamilton, A. J., Clissold, R. L., Inward, C. D., Caskey, F. J., & Ben-Shlomo, Y. (2017). Sociodemographic, psychologic health, and lifestyle outcomes in Young adults on renal replacement therapy. Clinical Journal of the American Society of Nephrology, 12(12), 1951–1961.CrossRefPubMedCentralGoogle Scholar
  10. 10.
    Broers, N. J. H., Usvyat, L. A., Kooman, J. P., van der Sande, F. M., Lacson, E. Jr., Kotanko, P., et al. (2015). Quality of life in dialysis patients: A retrospective cohort study. Nephron, 130(2), 105–112.CrossRefGoogle Scholar
  11. 11.
    Molnar-Varga, M., Molnar, M. Z., Szeifert, L., Kovacs, A. Z., Kelemen, A., Becze, A., et al. (2011). Health-related quality of life and clinical outcomes on kidney transplant recipients. American Journal of Kidney Diseases, 58(3), 444–452.CrossRefGoogle Scholar
  12. 12.
    Grincenkov, F. R., Fernandes, N., Pereira, B. S., Bastos, K., Lopes, A. A., Finkelstein, F. O., et al. (2015). Impacto f baseline health-related quality of life score on survival of incidente patients on peritoneal dialysis: A cohort study. Nephron, 129(2), 97–103.CrossRefGoogle Scholar
  13. 13.
    Lim, H. J., Koo, T. Y., Lee, J., Huh, K. H., Park, J. B., Cho, J., et al. (2016). Health-related quality of life of kidney transplantation patients: results from the korean cohort study for outcome in patients with kidney transplantation (KNOW-KT) study. In Transplantation Proceedings: Vol 48(3). (844–847). Amsterdam: Elsevier.Google Scholar
  14. 14.
    Rosenberger, J., van Dijk, J. P., Prihodova, L., Majernikova, M., Nagyova, I., Geckova, A. M., et al. (2010). Differences in perceived health status between kidney transplant recipients and dialyzed patients are based mainly on the selection process. Clinical Transplantation, 24(3), 358–365.CrossRefGoogle Scholar
  15. 15.
    Griva, K., Davenport, A., Harrison, M., & Newman, S. P. (2012). The impact of treatment transitions between dialysis and transplantation on illness cognitions and quality of life—a prospective study. British Journal of Health Psychology, 17(4), 812–827.CrossRefGoogle Scholar
  16. 16.
    Ortiz, F., Aronen, P., Koskinen, P. K., Malmström, R. K., Finne, P., Honkanen, E. O., et al. (2014). Health-related quality of life after kidney transplantation: Who benefits the most? Transplant International, 27(11), 1143–1151.CrossRefGoogle Scholar
  17. 17.
    von der Lippe, N., Waldum-Grevbo, B., Reisaeter, A. V., & Os, I. (2016). Is HRQOL in dialysis associated with patient survival or graft function after kidney transplantation? BMC Nephrology, 17, 94–103.CrossRefPubMedCentralGoogle Scholar
  18. 18.
    Bujang, M. A., Musa, R., Liu, W. J., Chew, T. F., Lim, C. T., & Morad, Z. (2015). Depression, anxiety and stress among patients with dialysis and the association with quality of life. Asian Journal of Psychiatry, 18, 49–52.CrossRefGoogle Scholar
  19. 19.
    Cukor, D., Coplan, J., Brown, C., Peterson, R. A., & Kimmel, P. L. (2008). Course of depression and anxiety diagnosis in patients treated with hemodialysis: A 16-mont follow-up. Clinical Journal of the American Society of Nephrology, 3(6), 1752–1758.CrossRefPubMedCentralGoogle Scholar
  20. 20.
    Griva, K., Kang, A. W., Yu, Z. L., Lee, V. Y., Zarogianis, S., Chan, M. C., et al. (2016). Predicting technique and patient survival over 12 months in peritoneal dialysis: The role of anxiety and depression. International Urology and Nephrology, 48(5), 791–796.CrossRefGoogle Scholar
  21. 21.
    Lacson Jr, E., Bruce, L., Li, N. C., Mooney, A., & Maddux, F. W. (2014). Depressive affect and hospitalization risk in incidente hemodialysis patients. Clinical Journal of the American Society of Nephrology, 29(10), 1713–1719.CrossRefGoogle Scholar
  22. 22.
    Machado, E. L., Gomes, I. C., Acurcio, F. A., César, C. C., Ameida, M. C. M., & Cherchiglia, M. L. (2012). Factors associated with waiting time and access to kidney transplants in Belo Horizonte, Minas Gerais State, Brazil. Cadernos de Saúde Pública, 28(12), 2315–2326.CrossRefGoogle Scholar
  23. 23.
    Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of Chronic Diseases, 40(5), 373–383.CrossRefGoogle Scholar
  24. 24.
    Detsky, A. S., McLaughlin, J. R., Baker, J. P., Johnston, N., Whittaker, S., Mendelson, R. A., et al. (1987). What is subjective global assessment of nutritional states? Journal of Parenteral and Enteral Nutrition, 11(1), 8–13.CrossRefGoogle Scholar
  25. 25.
    Ciconelli, R. M., Ferraz, M. B., Santos, W., Meinão, I., & Quaresma, M. R. (1999). Translation into Portuguese and validation of the generic questionnaire for assessing quality of life SF-36 (Brazil SF-36). Brazilian Journal of Rheumatology, 39(3), 143–150.Google Scholar
  26. 26.
    Wight, J. P., Edwards, L., Brazier, J., et al. (1998). The SF36 as an outcome measure of services for end stage renal failure. Quality Health Care, 7, 209–221.CrossRefGoogle Scholar
  27. 27.
    Neto, J. R. F., Ferraz, M., Cendoroglo, S., et al. (2000). Quality of life at initiation of maintenance dialysis treatment—a comparison between the SF-36 and the KDQ questionnaires. Quality of Life Research, 9, 1001–1107.CrossRefGoogle Scholar
  28. 28.
    Neipp, M., Jackobs, S., & Klempnauer, J. (2009). Renal transplantation today. Langenbeck’s. Archives of Surgery, 394(1), 1–16.CrossRefGoogle Scholar
  29. 29.
    Goodman, W. G., & Danovitch, G. M. (2005). Options for patients with kidney failure. In G. M. Danovitch (Ed.), Handbook of kidney transplantation (pp. 1–22). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  30. 30.
    Fisher, R., Gould, D., Wainwright, S., & Fallon, M. (1998). Quality of life after renal transplantation. Journal of Clinical Nursing, 7(6), 553–563.CrossRefGoogle Scholar
  31. 31.
    Muehrer, R. J., Schatell, D., Witten, B., Gangnon, R., Becker, B. N., & Hofmann, R. M. (2011). Factors affecting employment at initiation of dialysis. Clinical Journal of the American Society of Nephrology, 6(3), 489–496.CrossRefPubMedCentralGoogle Scholar
  32. 32.
    Harris, T. J., Nazir, R., Khetpal, P., Peterson, R. A., Chava, P., Patel, S. S., et al. (2012). Pain, sleep disturbance and survival in hemodialysis patients. Nephrology Dialysis Transplantation, 27(2), 758–765.CrossRefGoogle Scholar
  33. 33.
    Alavi, N. M., Aliakbarzadeh, Z., & Sharifi, K. (2009). Depression, anxiety, activities of daily living, and quality of life scores in patients undergoing renal replacement therapies. In Transplantation Proceedings, Vol 41(9), (pp. 3693–3696). Amsterdam: Elsevier.Google Scholar
  34. 34.
    Purnell, T. S., Auguste, P., Crews, D. C., Lamprea-Montealegre, J., Olufade, T., Greer, R., et al. (2013). Comparison of life participation activities among adults treated by hemodialysis, peritoneal dialysis, and kidney transplantation: a systematic review. American Journal of Kidney Diseases, 62(5), 953–973.CrossRefGoogle Scholar
  35. 35.
    Czyżewski, L., Sańko-Resmer, J., Wyzgał, J., & Kurowski, A. (2014). Assessment of health-related quality of life of patients after kidney transplantation in comparison with hemodialysis and peritoneal dialysis. Annals of transplantation, 19, 576–585.CrossRefGoogle Scholar
  36. 36.
    Neipp, M., Karavul, B., Jackobs, S., Meyer zu Vilsendorf, A., Richter, N., Becker, T., et al. (2006). Quality of life in adult transplant recipients more than 15 years after kidney transplantation. Transplantation, 81(12), 1640–1644.CrossRefGoogle Scholar
  37. 37.
    Ostrowiski, M., Wesołowski, T., Makar, D., & Bohatyrewicz, R. (2000). Changes in patients` quality of life after renal transplantation. In Transplantation Proceedings, Vol 32(6), (pp. 1371–1374). Amsterdam: Elsevier.Google Scholar
  38. 38.
    Aasebø, W., Homb-Vesteraas, N. A., Hartmann, A., & Stavem, K. (2009). Life situation and quality of life in young adult kidney transplant recipients. Nephrology Dialysis Transplantation, 24(1), 304–308.CrossRefGoogle Scholar
  39. 39.
    Karam, V., Gasquet, I., Delvart, V., Hiesse, C., Dorent, R., Danet, C., et al. (2003). Quality of life in adult survivors beyond 10 years after liver, kidney and heart transplantation. Transplantation, 76(12), 1699–1704.CrossRefGoogle Scholar
  40. 40.
    Chen, K. H., Weng, L. C., & Lee, S. (2010). Stress and stress-related factors of patients after renal transplantation in Taiwan: a cross-sectional study. Journal of Clinical Nursing, 19(17–18), 2539–2547.CrossRefGoogle Scholar
  41. 41.
    Barros, A., Costa, B. E., Mottin, C. C., & d’Avila, D. O. (2016). Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study. Revista Brasileira de Psiquiatria, 38(4), 301–306.CrossRefGoogle Scholar
  42. 42.
    Park, H. C., Lee, H., Lee, J. P., Kim, D. K., Oh, K. H., Joo, K. W., et al. (2012). Lower residual renal function is a risk fator for depression and impaired health-related quality of life in Korean peritoneal dialysis patients. Journal of Korean Medical Science, 27(1), 64–71.CrossRefGoogle Scholar
  43. 43.
    Mandel, E. L., Bernacki, R. E., & Block, S. D. (2017). Serious Illness Conversations in ESRD. Clinical Journal of the American Society of Nephrology, 12(5), 854–863.CrossRefGoogle Scholar
  44. 44.
    Wanner, C., Amann, K., & Shoji, T. (2016). The heart and vascular system in dialysis. The Lancet, 388(10041), 276–284.CrossRefGoogle Scholar
  45. 45.
    Østhus, T. B., Preljevic, V., Sandvik, T., Leivestad, L., Nordhus, T., Dammen, I. H., Os, T., I (2012). Mortality and health-related quality of life in prevalente dialysis patients: comparison between 12-items and 36-items short-form health survey. Health and Quality of Life Outcomes, 10, 46.CrossRefPubMedCentralGoogle Scholar
  46. 46.
    Coleman, D. (1993). Leisure based social support, leisure dispositions and health. Journal of Leisure Research, 25(4), 350–361.CrossRefGoogle Scholar
  47. 47.
    Derrett, S., Samaranayaka, A., Schollum, J. B. W., McNoe, B., Marshall, M. R., Williams, S., et al. (2017). Predictors of health deterioration among older adults after 12 months of dialysis therapy: A longitudinal cohort study from New Zealand. American Journal of Kidney Diseases, 70(6), 798–806.CrossRefGoogle Scholar
  48. 48.
    Chisholm-Burns, M. A., Erickson, S. R., Spivey, C. A., & Kaplan, B. Health-related quality of life and employment among renal transplant recipients. Clinical Transplantation, 26(3), 411–417.Google Scholar
  49. 49.
    Huang, B., Lai, B., Xu, L., Wang, Y., Cao, Y., Yan, P., et al. (2017). Low employment and low willingness of being reemployed in Chinese working-age maintained hemodialysis patients. Renal Failure, 39(1), 607–612.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Daniela Cristina Sampaio de Brito
    • 1
    Email author
  • Elaine Leandro Machado
    • 1
    • 3
  • Ilka Afonso Reis
    • 1
    • 4
  • Daniela Pena Moreira
    • 1
  • Thiago Henrique Mascarenhas Nébias
    • 1
  • Mariângela Leal Cherchiglia
    • 1
    • 2
    Email author
  1. 1.Grupo de Pesquisa em Economia e SaúdeBelo HorizonteBrazil
  2. 2.Department of Preventive and Social Medicine, Medical SchoolUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Department of Family Medicine, Mental Health and Public HealthUniversidade Federal de Ouro PretoOuro PretoBrazil
  4. 4.Department of StatisticsUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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