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Impact of Fatigue in Parkinson’s Disease: The Fatigue Impact Scale for Daily Use (D-FIS)

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Abstract

The Fatigue Impact Scale for Daily Use (D-FIS) was used in a cross-sectional study including 142 consecutive Parkinson’s disease (PD) patients. Usual clinical measures for PD, the Montgomery-Asberg Depression Rating Scale and the Parkinson’s Disease Questionnaire-8 items were applied. In addition to the D-FIS, patients with fatigue (67.6%, PWF) completed the Multidimensional Fatigue Inventory (MFI), a visual analogue scale for fatigue (VAS-F) and a Global Perception of Fatigue scale (GPF). Relevant psychometric D-FIS results were: floor effect = 4.2%; ceiling effect = 1.1%; skewness = 0.44; item homogeneity = 0.63; Cronbach’s α = 0.93; item-total correlation = 0.68 (item 1)−0.82 (item 8); standard error of measurement = 2.15; convergent validity with other fatigue measures = 0.54 [GPF]−0.62 [VAS-F] (p<0.001). In a multiple linear regression model, fatigue, depression, and disability independently influenced HRQoL, as measured by the PDQ-8. Patients on amantadine had lower prevalence of fatigue. In PD, D-FIS is a consistent and valid measure for fatigue, a frequent symptom previously found to impair patients’ HRQoL. Fatigue was also linked to depression and disability in this study.

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Abbreviations

FIS:

Fatigue Impact Scale

D-FIS:

Fatigue Impact Scale for daily use

GPF:

Global Perception of Fatigue scale

HRQoL:

Health-related quality of life

HY:

Hoehn and Yahr Classification

ISAPD:

Intermediate Scale for Assessment of Parkinson’s Disease

IR:

Interquartile rank

MADRS:

Montgomery-AsbergDepression Rating Scale

MFI:

Multidimensional Fatigue Inventory

MFI-GF:

Multidimensional Fatigue Inventory-General Fatigue

PD:

Parkinson’s disease

PDQ-8:

Parkinson’s Disease Questionnaire-8 Items

PDQ-8 SI:

Parkinson’s Disease Questionnaire-8 Items Summary Index

PWF:

Patients with fatigue

PNF:

Patients without fatigue

SES:

Schwab and England Scale

UPDRS:

Unified Parkinson’s Disease Rating Scale

VAS-F:

Visual analogue scale for fatigue

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Authors and Affiliations

  1. Unit of Neuroepidemiology, National Centre for Epidemiology, ISCIII (Madrid), The Spanish Network HOHSR, Spain

    Pablo Martinez-Martin & Belen Frades

  2. Department of Neurology, San Carlos University Teaching Hospital (Madrid), Spain

    Maria Jose Catalan

  3. Department of Neurology, Mostoles General Hospital (Madrid), Spain

    Julian Benito-Leon

  4. Department of Neurology, Virgen de las Nieves Hospital (Granada), Spain

    Angel Ortega Moreno

  5. Department of Neurology, Fuenlabrada General Hospital (Madrid), Spain

    Ivana Zamarbide & Fernando Alonso

  6. Department of Neurology, Nuestra Señora del Rosario Clinic (Madrid), Spain

    Esther Cubo

  7. Department of Neurology, Quiron Clinic (San Sebastian), Spain

    Nadeje van Blercon & Gurutz Linazasoro

  8. Department of Neurology, University Teaching Hospital (Malaga), Spain

    Victor Campos Arillo

  9. Department of Neurology, Severo Ochoa Hospital (Leganes, Madrid), Spain

    Margarita Pondal

  10. Department of Neurology, Jimenez Diaz Foundation (Madrid), Spain

    Pedro García Ruiz

  11. Unidad de Neuroepidemiología, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, C/Sinesio Delgado, 6, 28029, Madrid, Spain

    Pablo Martinez-Martin

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  1. Pablo Martinez-Martin
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  2. Maria Jose Catalan
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Correspondence to Pablo Martinez-Martin.

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Martinez-Martin, P., Catalan, M.J., Benito-Leon, J. et al. Impact of Fatigue in Parkinson’s Disease: The Fatigue Impact Scale for Daily Use (D-FIS). Qual Life Res 15, 597–606 (2006). https://doi.org/10.1007/s11136-005-4181-0

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