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Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study

  • Danica MichaličkováEmail author
  • Miona Belović
  • Nebojša Ilić
  • Jelena Kotur-Stevuljević
  • Ondřej Slanař
  • Sladjana Šobajić
Original Paper
  • 66 Downloads

Abstract

There is a growing body of evidence that tomato consumption reduces the risk of cardiovascular disease, through antioxidative, anti-inflammatory and hypotensive effects. We compared the effects of polyphenol-enriched and standard tomato juice on parameters of lipid and oxidative status and blood pressure in subjects with stage 1 hypertension. The experimental group (n = 13) was supplemented with 200 g of tomato fruit juice enriched with 1 g of ethanolic extract of whole tomato fruit, while the control group (n = 13) was consuming 200 g tomato fruit juice. Before and after the treatment, blood samples were collected, and blood pressure was measured. Markers of oxidative stress and antioxidative defense: paraoxonase (PON1), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), pro-oxidant-antioxidant balance (PAB) and C reactive protein (CRP) were determined in serum. Prothrombin time (PT) was measured in the whole blood samples. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant reduction in total cholesterol and LDL-C only in the control group at the end of the study. No significant differences were observed in the remainder of the assessed parameters along the study. In conclusion, tomato juice may have favorable effects on lipid metabolism, but polyphenol fortification does not constitute additional beneficial cardiovascular effects.

Keywords

Human intervention studies Polyphenols Lipids Cardiovascular risk 

Abbreviations

ANCOVA

Analysis of covariance

CRP

C-reactive protein

CVD

Cardiovascular diseases

DBP

Diastolic blood pressure

GAE

Gallic acid equivalents

HDL-C

High-density- cholesterol

INR

International normalized ratio

LDL-C

Low-density cholesterol

PAB

Pro-oxidant-antioxidant balance

PON1

Paraoxonase

PT

Prothrombin time

SBP

Systolic blood pressure

TAS

Total antioxidant status

TBARS

Thiobarbituric acid reactive substances

TC

Total cholesterol

TGC

Triglycerides

TOS

Total oxidant status

Notes

Acknowledgments

This work is supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project No. III 46001 and 175035) and the Charles University Project Progress Q25.

Compliance with Ethical Standards

Conflict of Interest

The present study does not constitute endorsement of the product by the authors or any conflict of interest.

Supplementary material

11130_2019_714_MOESM1_ESM.docx (28 kb)
ESM 1 (DOCX 27.5 kb)
11130_2019_714_MOESM2_ESM.docx (53 kb)
ESM 2 (DOCX 53.2 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Pharmacology, First Faculty of MedicineCharles UniversityPragueCzech Republic
  2. 2.Institute of Food TechnologyUniversity of Novi SadNovi SadSerbia
  3. 3.Department of Medical Biochemistry, Faculty of PharmacyUniversity of BelgradeBelgradeSerbia
  4. 4.Department of Bromatology, Faculty of PharmacyUniversity of BelgradeBelgradeSerbia

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