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Pituitary

pp 1–9 | Cite as

A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas

  • B. G. Sant’ AnnaEmail author
  • N. R. C. Musolino
  • M. R. Gadelha
  • C. Marques
  • M. Castro
  • P. C. L. Elias
  • L. Vilar
  • R. Lyra
  • M. R. A. Martins
  • A. R. P. Quidute
  • J. Abucham
  • D. Nazato
  • H. M. Garmes
  • M. L. C. Fontana
  • C. L. Boguszewski
  • C. B. Bueno
  • M. A. Czepielewski
  • E. S. Portes
  • V. S. Nunes-Nogueira
  • A. Ribeiro-OliveiraJr.
  • R. P. V. Francisco
  • M. D. Bronstein
  • A. Glezer
Article
  • 40 Downloads

Abstract

Objective

To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.

Methods

The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,

Results

We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.

Conclusions

Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.

Keywords

Prolactinoma Pregnancy Dopamine agonist Cabergoline Miscarriage Malformation 

Notes

Funding

No financial support.

Compliance with ethical standards

Conflict of interest

Musolino NRC. received fees as a speaker for Pfizer. Ribeiro-Oliveira Júnior A. received fees as a speaker for Novartis and IPSEN. He is currently an employee of IPSEN Biosciences in the USA, and data was generated before his joining to IPSEN. We certify that nor other co-authors have a conflict of interest as described above that is relevant to the subject matter or materials included in this Work.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • B. G. Sant’ Anna
    • 1
    Email author
  • N. R. C. Musolino
    • 2
  • M. R. Gadelha
    • 3
  • C. Marques
    • 3
  • M. Castro
    • 4
  • P. C. L. Elias
    • 4
  • L. Vilar
    • 5
  • R. Lyra
    • 5
  • M. R. A. Martins
    • 6
  • A. R. P. Quidute
    • 6
  • J. Abucham
    • 7
  • D. Nazato
    • 7
  • H. M. Garmes
    • 8
  • M. L. C. Fontana
    • 8
  • C. L. Boguszewski
    • 9
  • C. B. Bueno
    • 10
  • M. A. Czepielewski
    • 11
  • E. S. Portes
    • 12
  • V. S. Nunes-Nogueira
    • 13
  • A. Ribeiro-OliveiraJr.
    • 14
  • R. P. V. Francisco
    • 15
  • M. D. Bronstein
    • 1
  • A. Glezer
    • 1
  1. 1.Division of Endocrinology and Metabolism, Hospital das ClinicasNeuroendocrine Unit, University of Sao Paulo Medical SchoolSao PauloBrazil
  2. 2.Division of Neurosurgery, Institute of PsychiatryUniversity of Sao Paulo Medical SchoolSao PauloBrazil
  3. 3.Federal University of Rio de JaneiroRio de JaneiroBrazil
  4. 4.University of Sao Paulo Medical School of Ribeirao PretoRibeirao PretoBrazil
  5. 5.Federal University of PernambucoRecifeBrazil
  6. 6.Federal University of CearaFortalezaBrazil
  7. 7.Escola Paulista de Medicina, Universidade Federal de São PauloSao PauloBrazil
  8. 8.State University of CampinasCampinasBrazil
  9. 9.Endocrine Division (SEMPR), Department of Internal MedicineFederal University of ParanaCuritibaBrazil
  10. 10.Irmandade da Santa Casa de Misericórdia de São PauloSao PauloBrazil
  11. 11.Division of EndocrinologyHospital de Clinicas de Porto Alegre (UFRGS)Porto AlegreBrazil
  12. 12.Institute of Medical Assistance to the State Public HospitalSao PauloBrazil
  13. 13.São Paulo State University (UNESP), Medical SchoolBotucatuBrazil
  14. 14.Federal University of Minas GeraisBelo HorizonteBrazil
  15. 15.Disciplina de Obstetrícia, Departamento de Obstetrícia e GinecologiaFaculdade de Medicina (FMUSP), Universidade de São PauloSao PauloBrazil

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