Surgical resection of granular cell tumor of the sellar region: three indications
This case series evaluates the surgical management of granular cell tumor (GCT) of the sellar region. This rare entity presents a unique diagnostic and surgical challenge.
Institutional neuropathology databases at Brigham and Women’s Hospital and Massachusetts General Hospital were searched for cases with a tissue diagnosis of GCT, and with a location in the sellar region. Patient, treatment, tumor, and follow-up data were extracted.
Three patients had a diagnosis of GCT of the sellar region occurring over an 18-year period. All three patients were followed postoperatively at our multidisciplinary pituitary center (median follow-up = 30 months; range 12–30 months). Hormonal disturbances, an incidental lesion requiring diagnosis, and neurological symptoms were indications for surgery in these patients. Two patients underwent a craniotomy and one underwent endoscopic transsphenoidal surgery. All three patients were free of tumor recurrence at last follow-up. In one case tested, positive thyroid transcription factor-1 (TTF-1) immunohistochemistry was observed.
GCT is generally a benign tumor of the sellar region. Surgical resection is the standard treatment, more recently with transsphenoidal surgery when indicated. Surgical resection results in optimal outcome for patients.
KeywordsGranular cell tumor Transsphenoidal Pituicytoma Radiation
NIH Training Grant T32 CA009001 (DJC).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
IRB approval was obtained from Brigham & Women’s Hospital (Partners) for the search and use of institutional database data. (IRB Approval #: 2015P002352).
- 1.Lloyd RV, Osamura RY, Kloppel G, Rosai J (2017) WHO classification of tumours of the endocrine organs, 4th edn. International Agency for Research on Cancer, LyonGoogle Scholar
- 8.Sternberg C (1921) Ein choristom der neurohypophyse bei ausgebre-iteten oedemen. Ebl Alleg Path Anat 31:585–589Google Scholar