Ectopic pituitary adenomas: common presentations of a rare entity
Ectopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size.
We performed a single-center retrospective analysis of patients with diagnosis of ectopic pituitary adenoma from 2001 to 2018.
Five patients were identified with EPA: a 48-year-old woman with suprasellar EPA treated with transsphenoidal removal of the tumor, a 44-year-old woman with cavernous EPA treated with transsphenoidal removal of the tumor, a 48-year-old woman with sphenoid EPA treated with cabergoline, a 45-year-old man with clival EPA treated with cabergoline and transsphenoidal surgical resection, and a 54-year-old man with clival EPA treated with cabergoline therapy.
EPA should be considered as a differential diagnosis of juxta-sellar lesions. Appropriate hormonal testing may lead to early diagnosis, avoidance of unnecessary biopsy or surgery, and improved outcomes.
KeywordsEctopic pituitary adenoma Extrasellar pituitary adenoma Clival pituitary adenoma Suprasellar pituitary adenoma Sphenoid pituitary adenoma Prolactinoma
This research did not receive any specific grant from funding agencies in the public, commercial or non-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.ElSayed SA, Bhimji SS (2018) Physiology, Pituitary Gland. StatPearls Publishing LLC, Treasure IslandGoogle Scholar
- 3.Ilahi S, Ilahi TB (2018) Anatomy, Adenohypophysis (Pars Anterior, Anterior Pituitary). StatPearls Publishing LLC, Treasure IslandGoogle Scholar
- 6.Larkin S, Ansorge O (2017) Development and microscopic anatomy of the pituitary gland. Endotext. https://www.endotext.org. Accessed 1 Feb 2019
- 8.Patel H, Tiwari V (2018) Physiology, Posterior Pituitary. StatPearls Publishing LLC, Treasure IslandGoogle Scholar
- 10.Melchionna RH, Moore RA (1938) The pharyngeal pituitary gland. Am J Pathol 14(6):763–772 761Google Scholar
- 11.Hou L, Harshbarger T, Herrick MK, Tse V (2002) Suprasellar adrenocorticotropic hormone-secreting ectopic pituitary adenoma: case report and literature review. Neurosurgery 50(3):618–625Google Scholar
- 18.Thompson LD, Seethala RR, Muller S (2012) Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the english literature. Head Neck Pathol 6(1):75–100. https://doi.org/10.1007/s12105-012-0336-9 CrossRefGoogle Scholar
- 21.Guerrero CA, Krayenbuhl N, Husain M, Krisht AF (2007) Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. Neurosurgery 61(4):E879; (discussion E879). https://doi.org/10.1227/01.neu.0000298921.47495.42 CrossRefGoogle Scholar
- 26.Sakakibara Y, Sekino H, Taguchi Y, Tadokoro M (2002) Unilateral exophthalmos caused by a prolactin producing ectopic pituitary adenoma: case report. No Shinkei Geka Neurol surg 30(6):623–628Google Scholar
- 27.Hanaoka Y, Ogiwara T, Kakizawa Y, Nagm A, Seguchi T, Aoyama T, Koyama J-i, Sato A, Hongo K (2018) Calcified ectopic TSH-secreting pituitary adenoma mimicking craniopharyngioma: a rare case report and literature review. Acta Neurochir 160(10):2001–2005. https://doi.org/10.1007/s00701-018-3638-1 CrossRefGoogle Scholar