, Volume 22, Issue 4, pp 339–343 | Cite as

Ectopic pituitary adenomas: common presentations of a rare entity

  • Ali Agely
  • Lela Okromelidze
  • George K. Vilanilam
  • Kaisorn L. Chaichana
  • Erik H. Middlebrooks
  • Vivek GuptaEmail author



Ectopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size.


We performed a single-center retrospective analysis of patients with diagnosis of ectopic pituitary adenoma from 2001 to 2018.


Five patients were identified with EPA: a 48-year-old woman with suprasellar EPA treated with transsphenoidal removal of the tumor, a 44-year-old woman with cavernous EPA treated with transsphenoidal removal of the tumor, a 48-year-old woman with sphenoid EPA treated with cabergoline, a 45-year-old man with clival EPA treated with cabergoline and transsphenoidal surgical resection, and a 54-year-old man with clival EPA treated with cabergoline therapy.


EPA should be considered as a differential diagnosis of juxta-sellar lesions. Appropriate hormonal testing may lead to early diagnosis, avoidance of unnecessary biopsy or surgery, and improved outcomes.


Ectopic pituitary adenoma Extrasellar pituitary adenoma Clival pituitary adenoma Suprasellar pituitary adenoma Sphenoid pituitary adenoma Prolactinoma 



This research did not receive any specific grant from funding agencies in the public, commercial or non-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of RadiologyMayo ClinicJacksonvilleUSA
  2. 2.Department of NeurologyMayo ClinicJacksonvilleUSA
  3. 3.Department of Neurologic SurgeryMayo ClinicJacksonvilleUSA
  4. 4.Mayo ClinicJacksonvilleUSA

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