Phytochemistry Reviews

, Volume 18, Issue 3, pp 665–842 | Cite as

Quinone diterpenes from Salvia species: chemistry, botany, and biological activity

  • Angela Bisio
  • Francesca Pedrelli
  • Massimiliano D’Ambola
  • Fabiana Labanca
  • Anna Maria Schito
  • Rafaël Govaerts
  • Nunziatina De TommasiEmail author
  • Luigi Milella


A total of 175 abietane quinone diterpenes with ortho- or para-quinone chromophore, namely 11,12-ortho-quinone abietane, 11,14-para-quinone abietane, seco-abietane and abeo-abietanes quinones were surveyed from 130 species of Salvia of central Asia/Mediterranean area, eastern Asia, and Central and South America. An organized information on the phytochemistry and the biological activities, i.e. anti-cancer, antioxidant, anxiolytic and antidepressant, anti-obesity, antinflammatory, as well as antimicrobial and toxicological aspects of these compounds was provided. Due to the many nomenclatural mistakes caused by the abundance of data, and the need to provide the plant knowledge for further chemotaxonomic studies, the results about the botany and the taxonomy of the plant source of these compounds were also summarized.


Salvia Abietane quinone diterpenes Taxonomical information Antimicrobial Biological activity 



This study was funded by INTERREG V-A Francia-Italia (ALCOTRA) (2014–2020) Project “ANTEA–Attività innovative per lo sviluppo della filiera transfrontaliera del fiore edule” (No. 11039).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Dipartimento di FarmaciaUniversità di GenovaGenoaItaly
  2. 2.Dipartimento di FarmaciaUniversità di SalernoFiscianoItaly
  3. 3.Dipartimento di ScienzeUniversità degli Studi della BasilicataPotenzaItaly
  4. 4.Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Sezione di MicrobiologiaUniversità di GenovaGenoaItaly
  5. 5.Biodiversity Informatics and Spatial Analysis Royal Botanic GardensKew Jodrell LaboratoryRichmondUK

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