Origanum spp.: an update of their chemical and biological profiles

  • Mariangela Marrelli
  • Giancarlo A. Statti
  • Filomena Conforti
Article
  • 21 Downloads

Abstract

The purpose of this review is to provide an overview of most recent studies about potential pharmaceutical applications of plants belonging to Origanum genus. Oregano is one of the most famous and economically important culinary herbs in the world. The genus Origanum includes more than 70 species mainly distributed around the Mediterranean region. The vernacular name “oregano” is attributed to a vast number of species. O. vulgare L. is the most variable species of the genus and the most commonly known as oregano in most countries. Today, it is generally accepted that oregano is a characteristic flavour produced by a number of plant species that yield carvacrol-rich essential oils. The genus Origanum is characterised by a large morphological and chemical diversity. Because of their several biological activities, such as antimicrobial, expectorant, antispasmodic and carminative, Origanum species have been used in traditional medicine to treat various diseases. The botany and chemotaxonomy of the species are thoroughly reported, along with chemical constituents. The in vitro and in vivo effects of Origanum extracts are presented and discussed.

Keywords

Biological activity Essential oil Origanum sp. Phenols Terpenes 

Abbreviations

5RP7

H-ras transformed rat embryonic fibroblasts

BHA

Butylated hydroxyanisole

BHT

Butylated hydroxytoluene

C6

Rat brain tumour cell line

DPPH

1,1-Diphenyl-2-picrylhydrazil radical

GLUT-2

Glucose transporter-2

HEK293

Human embryonic kidney cells 

HeLa

Human cervix carcinoma cell line

HepG2

Hepatocarcinoma cell line

HepG2

Human liver cancer cell line

LoVo

Colon carcinoma cell line

LPL

Lipoprotein lipase

LPS

Lipopolysaccharide

MCF

Minimal fungicidal concentration

MiaPaca-2

Human pancreas carcinoma cell line

MI

Minimal inhibitory concentration

MID

Minimum inhibitory dose

NO

Nitric oxide

PG

Propyl gallate

RAW 264.7

Mouse macrophage cell line

ROS

Reactive oxygen species

TBHQ

tert-Butylhdroquinone

Vero

African green monkey kidney epithelium cells

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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacy, Health and Nutritional SciencesUniversity of CalabriaRendeItaly

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