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Interrater reliability of a tool to assess omission of prescription and inappropriate prescriptions in paediatrics

  • Aurore Berthe-AucejoEmail author
  • N. P. K. Khan Nguyen
  • François Angoulvant
  • Rym Boulkedid
  • Xavier Bellettre
  • Thomas Weil
  • Corinne Alberti
  • Olivier Bourdon
  • Sonia Prot-Labarthe
Research Article
  • 34 Downloads

Abstract

Background Potentially inappropriate medication (PIM) and potential prescription omission (PPO) are common issues in pharmacotherapy in vulnerable populations. A first tool to assess PIM’s and PPO’s targeting pediatric populations: POPI «Pediatrics Omission of Prescriptions and Inappropriate Prescriptions» was created in 2014. Objective This study aimed to evaluate inter-rater reliability between healthcare professionals who apply POPI. Setting: Mother and child emergency ward of a university hospital. Method Twenty cases with or without PIM or PPO were identified in a previous retrospective PIM-PPO prevalence study on 15,973 patients. One doctor and one pharmacist, who participated in the creation of POPI tool, identified PIM and PPO (“gold standard response”). These cases were reviewed independently by eleven clinicians (generalists, pediatricians, pharmacists, residents), with no previous experience of this tool. Interrater agreement was calculated by using the Kappa agreement test. Main outcome measure: Inter-clinician agreement. Results A high level of agreement of PIM and PPO detection was recorded (PIM: median = 0.80; PPO: median = 0.71). Conclusion POPI demonstrated a good interrater reliability. This validation by many clinicians proves that POPI is a reliable tool. Other multicenter and prospective studies should be conducted to evaluate economical and clinical impacts of POPI.

Keywords

France Inappropriate prescription Inter-rater reliability Pharmacist Physician 

Notes

Acknowledgements

We would like to thank Dr Dominique Navas, Dr Henri Hollenberg, Dr Lila Alloing, Dr Romain Basmaci, Dr Dominique Girardon, Dr Lucie Vuillemin, Dr Philippe Zerr, Dr Marie-Aliette Dommergues, Dr Sandrine Masseron, Dr Julie Sommet, Dr Lise Durand for their participation in this study.

Funding

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Conflicts of interest

All authors declare that they have no conflict of interest.

Supplementary material

11096_2019_819_MOESM1_ESM.docx (23 kb)
Supplementary material 1 (DOCX 23 kb)

References

  1. 1.
    Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology—drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349:1157–67.CrossRefGoogle Scholar
  2. 2.
    Shah SS, Hall M, Goodman DM, Feuer P, Sharma V, Fargason C, et al. Off-label drug use in hospitalized children. Arch Pediatr Adolesc Med. 2007;161:282–90.CrossRefGoogle Scholar
  3. 3.
    Horen B, Montastruc J-L, Lapeyre-Mestre M. Adverse drug reactions and off-label drug use in paediatric outpatients. Br J Clin Pharmacol. 2002;54:665–70.CrossRefGoogle Scholar
  4. 4.
    Gallagher P, O’Mahony D. STOPP (Screening Tool of Older Persons’ potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers’ criteria. Age Ageing. 2008;37:673–9.CrossRefGoogle Scholar
  5. 5.
    Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med. 1991;151:1825–32.CrossRefGoogle Scholar
  6. 6.
    Inappropriate Prescribing—MeSH—NCBI [Internet]. [cited 2015 Apr 13]. http://www.ncbi.nlm.nih.gov/mesh?term=inappropriate%20prescription.
  7. 7.
    Legrain S others. Consommation médicamenteuse chez le sujet âgé. Consommation, prescription, iatrogénie et observance. 2005 [Medication use in geriatric population. use, prescription, medicine-related illness, observance] [Internet]. http://www.has-sante.fr/portail/upload/docs/application/pdf/pmsa_synth_biblio_2006_08_28__16_44_51_580.pdf.
  8. 8.
    Direction de la recherche, des études, des évaluation et des statistiques. Enquête Nationale sur les Événements Indésirables graves associés aux Soins - Description des résultats 2009 -[National survey into adverse events related to medical care - Results 2009] [Internet]. [cited 2015 Nov 11]. http://drees.social-sante.gouv.fr/IMG/pdf/serieetud110.pdf.
  9. 9.
    Reidenberg MM. Can the selection and use of essential medicines decrease inappropriate drug use? Clin Pharmacol Ther. 2009;85:581–3.CrossRefGoogle Scholar
  10. 10.
    Gore R, Chugh PK, Tripathi CD, Lhamo Y, Gautam S. Pediatric off-label and unlicensed drug use and its implications. Curr Clin Pharmacol. 2017;12:18–25.CrossRefGoogle Scholar
  11. 11.
    Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, Uttech KM, et al. A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol. 1994;47:891–6.CrossRefGoogle Scholar
  12. 12.
    Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46:72–83.CrossRefGoogle Scholar
  13. 13.
    Dalleur O, Boland B, Losseau C, Henrard S, Wouters D, Speybroeck N, et al. Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging. 2014;31:291–8.CrossRefGoogle Scholar
  14. 14.
    Lang P-O, Hasso Y, Belmin J, Payot I, Baeyens J-P, Vogt-Ferrier N, et al. STOPP-START: adaptation of a French language screening tool for detecting inappropriate prescriptions in older people. Can J Public Health Rev Can Santé Publique. 2009;100:426–31.Google Scholar
  15. 15.
    Gallagher P, Lang PO, Cherubini A, Topinková E, Cruz-Jentoft A, Montero Errasquín B, et al. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol. 2011;67:1175–88.CrossRefGoogle Scholar
  16. 16.
    Josseran L, Caillère N, Ilef D. Emergency surveillance—Oscour Network National results 2004/2008 [Internet]. French Institut for Public Health Surveillance; 2008. http://invs.santepubliquefrance.fr/publications/2008/plaquette_resultats_oscour/plaquette_resultats_oscour_en.pdf.
  17. 17.
    Prot-Labarthe S, Weil T, Angoulvant F, Boulkedid R, Alberti C, Bourdon O. POPI (Pediatrics: Omission of Prescriptions and Inappropriate Prescriptions): development of a tool to identify inappropriate prescribing. PLoS ONE. 2014;9:e101171.CrossRefGoogle Scholar
  18. 18.
    Prot-Labarthe S, Vercheval C, Angoulvant F, Brion F. Bourdon O [POPI: a tool to identify potentially inappropriate prescribing practices for children]. Arch Pédiatrie. 2011;18:1231–2.CrossRefGoogle Scholar
  19. 19.
    Gallagher P, Baeyens J-P, Topinkova E, Madlova P, Cherubini A, Gasperini B, et al. Inter-rater reliability of STOPP (Screening Tool of Older Persons’ Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) criteria amongst physicians in six European countries. Age Ageing. 2009;38:603–6.CrossRefGoogle Scholar
  20. 20.
    Ryan C, O’Mahony D, Byrne S. Application of STOPP and START criteria: interrater reliability among pharmacists. Ann Pharmacother. 2009;43:1239–44.CrossRefGoogle Scholar
  21. 21.
    SurveyMonkey. SurveyMonkey [Internet]. 2015. https://fr.surveymonkey.com/r/86P7BQC.
  22. 22.
    Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRefGoogle Scholar
  23. 23.
    Scott I, Jayathissa S. Quality of drug prescribing in older patients: is there a problem and can we improve it? Intern Med J. 2010;40:7–18.CrossRefGoogle Scholar
  24. 24.
    Onder G, van der Cammen TJM, Petrovic M, Somers A, Rajkumar C. Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing. 2013;42:284–91.CrossRefGoogle Scholar
  25. 25.
    Berthe-Aucejo A, Girard D, Lorrot M, Bellettre X, Faye A, Mercier JC, et al. Evaluation of frequency of paediatric oral liquid medication dosing errors by caregivers: amoxicillin and josamycin. Arch Dis Child. 2016;101:481–90.CrossRefGoogle Scholar
  26. 26.
    Smartphone application of primary care guidelines used in education of medical students. PubMed—NCBI [Internet]. [cited 2018 Feb 6]. https://www.ncbi.nlm.nih.gov/pubmed/23467657.
  27. 27.
    Enhancing Pharmacy Student Learning and Perceptions of Medical Apps.—PubMed—NCBI [Internet]. [cited 2018 Feb 6]. https://www.ncbi.nlm.nih.gov/pubmed/27174684.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Aurore Berthe-Aucejo
    • 1
    • 2
    Email author
  • N. P. K. Khan Nguyen
    • 1
  • François Angoulvant
    • 2
    • 3
  • Rym Boulkedid
    • 2
    • 4
  • Xavier Bellettre
    • 5
  • Thomas Weil
    • 1
  • Corinne Alberti
    • 2
    • 4
  • Olivier Bourdon
    • 1
    • 6
    • 7
    • 8
  • Sonia Prot-Labarthe
    • 1
    • 2
    • 6
  1. 1.Department of PharmacyRobert-Debré Hospital AP-HPParisFrance
  2. 2.U1123, INSERM ECEVEParisFrance
  3. 3.Department of Pediatric EmergencyNecker-Enfants Malades Hospital AP-HP, Paris Descartes UniversityParisFrance
  4. 4.Clinical Epidemiology UnitRobert-Debré Hospital AP-HPParisFrance
  5. 5.Emergency UnitRobert-Debré Hospital AP-HPParisFrance
  6. 6.Groupe Pédiatrie de la Société Française de Pharmacie CliniqueParisFrance
  7. 7.Clinical PharmacyParis Descartes UniversityParisFrance
  8. 8.Laboratoire Educations et Pratiques de SantéParis XIII UniversityBobignyFrance

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