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International Journal of Clinical Pharmacy

, Volume 40, Issue 5, pp 1265–1271 | Cite as

Olanzapine as antiemetic drug in oncology: a retrospective study in non-responders to standard antiemetic therapy

  • Florian SlimanoEmail author
  • Florence Netzer
  • Isabelle Borget
  • François Lemare
  • Benjamin Besse
Research Article

Abstract

Background The role of olanzapine in the treatment of chemotherapy-induced nausea and vomiting (CINV) in addition to the antiemetic therapeutic combination with aprepitant, setrons, and corticosteroids has not been well defined. Objective To investigate the effectiveness of the addition of olanzapine to a standard triplet therapy for the prevention of CINV in patients who experienced CINV during their first chemotherapy course, despite receiving a well-managed prevention protocol. Setting One comprehensive cancer centre in France. Method In a retrospective study with comparator, patients with a high risk of emesis were assigned to two groups during two different 6-month periods, before and after the introduction of olanzapine in clinical practice, respectively. In the olanzapine group, the antiemetic protocol for the second course of chemotherapy was reinforced by the addition of olanzapine at 5 mg/day from day 1 to 5 in contrast with the control group. Main outcome measure The proportion of patients who experienced neither nausea nor emesis during the delayed phase (24–120 h). Results The 25 patients in each group exhibited comparable characteristics and emetic chemotherapy level. During the first course, no significant difference was observed. During the second course, nausea and vomiting were ameliorated in 12 patients in the olanzapine group and 4 patients in the control group (p < 0.05). Nausea (12 vs. 4, p < 0.05) and vomiting (18 vs. 11, p < 0.05) also significantly improved. In the OLZ group, no adverse event was linked to olanzapine use. Conclusion The addition of olanzapine was observed to effectively restore CINV prevention in patients who did not respond to standard antiemetic therapy.

Keywords

Antiemetics Chemotherapy-induced nausea and vomiting France Olanzapine Secondary prophylaxis 

Notes

Acknowledgements

Mr. Vincent Blazy for the help in software data extraction.

Funding

None.

Conflicts of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Clinical PharmacyGustave Roussy Cancer CampusVillejuifFrance
  2. 2.Faculty of PharmacyReims UniversityReimsFrance
  3. 3.Department of Biostatistic and Epidemiology, Gustave Roussy Cancer Campus, and INSERM U 1018Paris-Sud, Paris-Saclay UniversityChâtenay-MalabryFrance
  4. 4.GRADESParis-Sud, Paris-Saclay UniversityChâtenay-MalabryFrance
  5. 5.Faculty of PharmacyParis Descartes UniversityParisFrance
  6. 6.Department of Medical OncologyGustave Roussy Cancer CampusVillejuifFrance
  7. 7.Faculty of MedicineParis-Sud, Paris-Saclay UniversityLe Kremlin-Bicêtre CedexFrance

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