Background Many excipients have been reported to induce drug hypersensitivity (e.g. colouring additives, preservatives). Colloidal silica has never been reported to induce drug hypersensitivity reactions. Case report We report herein a 40-year-old patient who developed a skin eruption 2 days after Voltarene® (diclofenac) intake, confirmed by a positive patch test. Investigation of cross reactivity, assessed by patch testing to other non steroidal anti-inflammatory drugs, have showed a positive reaction only to piroxicam (Piroxen®), ketoprofen (Oki®) and indometacin (Indocid®). A hypersensivity to colloidal silica, a common excipient, was suspected. A patch test to this compound was performed showing a positive reaction. Conclusion Colloidal silica, a compound widely used in drug manufacturing, could be another culprit excipient in inducing skin hypersensitivity reactions.
Colloidal silica Drug hypersensitivity reaction Patch test
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The authors are greatly indebted to Professor Adel Rdissi for his help with improving the language used in this article.
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