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International Journal of Clinical Pharmacy

, Volume 37, Issue 6, pp 996–999 | Cite as

An observational study of cutaneous adverse drug reactions in a teaching hospital

  • Deepti Chopra
  • Vibha Sharma
  • Rohan Kapoor
  • Shridhar DwivediEmail author
Short Research Report

Abstract

Background Pharmacotherapy is often impeded by adverse drug reactions (ADRs). Among these ADRs cutaneous reactions are the major class being easily identified and reported. If not noted early it has potential to develop into serious lesions. Objective To evaluate the clinical patterns of various drug induced cutaneous reactions. Setting A Teaching hospital in India. Methods All suspected cutaneous reactions to systemic drugs which were submitted to the ADR monitoring centre during a 6-month period (March 2014–August 2014) were analysed. Causality relationship, severity assessment and preventability assessment was also done. Results Out of 134 cutaneous ADRs, 56 % occurred in females, majority of cases were found in the age group of 41–50 years. The most common type of ADR was maculopapular rash (46.3 %) and majorly implicated drug class was antibiotics (51.3 %). Most (72.3 %) were mild. Polypharmacy and multiple comorbid conditions were important predisposing factors. Over half of the cases (58 %) were not preventable. Conclusion Cutaneous adverse reaction patterns and their causes vary as the result of changing use of drugs. In India, antibiotics are responsible for the majority of the cutaneous adverse drug reactions, and maculopapular rash is the side effect that is most reported.

Keywords

ADR Causality Cutaneous reactions India Maculopapular rash Pharmacovigilance India 

Notes

Funding

None.

Conflicts of interest

None.

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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  • Deepti Chopra
    • 1
  • Vibha Sharma
    • 2
  • Rohan Kapoor
    • 3
  • Shridhar Dwivedi
    • 4
    Email author
  1. 1.Department of Pharmacology, Hamdard Institute of Medical Sciences and ResearchJamia HamdardNew DelhiIndia
  2. 2.DGHSCDSCO (HQ)New DelhiIndia
  3. 3.HIMSRJamia HamdardNew DelhiIndia
  4. 4.Department of Medicine and Preventive Cardiology, Hamdard Institute of Medical Sciences and ResearchJamia HamdardNew DelhiIndia

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