International Journal of Clinical Pharmacy

, Volume 37, Issue 5, pp 675–677 | Cite as

Renal function overestimation in underweight and/or non-ambulatory patients

  • Fazlollah KeshavarziEmail author


Creatinine clearance estimation is widely used to evaluate the renal function of the patients in order to initiate or adjust the drugs dosage. However serum creatinine, as a muscle metabolism by-product, may not be a reliable parameter in underweight and/or non-ambulatory patients, such as geriatric, acquired immunodeficiency syndrome patients and bed-confined and cachexic cases. To avoid overestimation of the renal function in those patients, serum cystatin C can be considered as a sensitive and accurate alternative for serum creatinine.


Bed-confined Creatinine clearance Cystatin C Renal function overestimation Underweight patients 




Conflicts of interest

No any competing interest is declared.


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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  1. 1.UCSI UniversityKuala LumpurMalaysia

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