Drug-induced anaemia: a decade review of reporting to the Italian Pharmacovigilance data-base
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Background Studies investigating drug-induced anaemia are relatively scarce and mostly related to specific drugs or patients with specific pathologies. Objective To analyse all reports of suspected drug-induced anaemias recorded in the National Pharmacovigilance Database of the Italian Medicines Agency. Method The cases of suspected drug-induced anaemias analysed were those retrieved from the Italian National Pharmacovigilance Database from January 2001 to December 2013. Results The active substances involved were 375 in 3,305 reports of drug-induced anaemia; of these, 72 % were reported as serious. In 35 % of the reports patients were in polytherapy. In 24.3 % of the cases relevant DDIs were identified. We found a PRR value of 57.29 for peginterferon alfa-2a, of 12.57 for ribavirin, of 13 for flu vaccine for the occurrence of autoimmune haemolytic anaemia. The drugs mostly involved in the cases where the Naranjo causality was probable or possible were acetylsalicylic acid, warfarin, ribavirin, peginterferon alfa-2a, carboplatin and acenocoumarol. Conclusions A possible signal was detected for peginterferon alfa-2a, ribavirin and flu vaccine in the occurrence of autoimmune haemolytic anaemia. A great involvement of clopidogrel, enoxaparin, warfarin, ticlopidine and acetylsalicylic acid in preventable DDI-induced anaemia was detected, highlighting a poor awareness among healthcare providers on this issue.
KeywordsAdverse drug reaction Anaemia Italy Pharmacovigilance
This study was supported by the Italian Medicines Agency (AIFA) and by the Italian Ministry of Health (RC 2014 to EC).
Conflicts of interest
The author(s) declare that they have no competing interests.
- 2.Leisegang R, Blockman M. Primary drug-induced anaemia and the importance of adverse drug reaction (ADR) monitoring. Contin Med Educ. 2008;26(5):257.Google Scholar
- 3.The Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring. The WHO adverse reaction terminology. http://www.umcproducts.com/graphics/3149.pdf(2014). Accessed 10 March 2014.
- 4.Development CoreTeam R. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2011.Google Scholar