International Journal of Clinical Pharmacy

, Volume 36, Issue 6, pp 1141–1143 | Cite as

Acute and fatal thrombocytopenic thrombotic purpura after a single dose of pemetrexed

  • Irene Alabiso
  • Chiara BaratelliEmail author
  • Maria Pia Brizzi
  • Raffaella Bitossi
  • Azzurra Ottone
  • Marco Tampellini
Case Report


Case Thrombocytopenic thrombotic purpura (TTP), a life-threatening event consisting of disseminated vascular thrombosis, has never been described before as a possible side effect of the anticancer drug pemetrexed. A 70 years old patient affected by a poorly differentiated non small cell lung cancer, subjected to his first pemetrexed administration, developed an acute thrombocytopenic thrombotic purpura, fatal in a few hours. Conclusions Pemetrexed can cause TTP. Clinicians have to be alert for the rapid onset and aggressiveness of this possible side effect. It is difficult to recognise the first signs and symptoms.


Non small cell lung cancer Pemetrexed Thrombocytopenic thrombotic purpura 


Conflicts of interest





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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2014

Authors and Affiliations

  • Irene Alabiso
    • 1
  • Chiara Baratelli
    • 2
    Email author
  • Maria Pia Brizzi
    • 2
  • Raffaella Bitossi
    • 2
  • Azzurra Ottone
    • 2
  • Marco Tampellini
    • 2
  1. 1.Ospedale San Giovanni BoscoTurinItaly
  2. 2.AOU San Luigi GonzagaOrbassanoItaly

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