International Journal of Clinical Pharmacy

, Volume 36, Issue 1, pp 55–69 | Cite as

Assessing medication adherence: options to consider

  • Audrey Lehmann
  • Parisa Aslani
  • Rana Ahmed
  • Jennifer Celio
  • Aurelie Gauchet
  • Pierrick Bedouch
  • Olivier Bugnon
  • Benoît Allenet
  • Marie Paule SchneiderEmail author
Review Article


Background Adherence to chronic therapy is a key determinant of patient health outcomes in chronic disease. However, only about 50 % of patients adhere to chronic therapy. One of the challenges in promoting adherence is having an accurate understanding of adherence rates and the factors that contribute to non-adherence. There are many measures available to assess patient medication adherence. Aim of the review This review aims to present the commonly used indirect methods available for measuring medication adherence in routine healthcare and research studies. Method A literature review on medication adherence measures in patient populations with chronic conditions taking chronic medications was conducted through Medline (2003–2013). A complementary manual search of references cited in the retrieved studies was performed in order to identify any additional studies. Results Of the 238 initial Medline search results, 57 full texts were retrieved. Forty-seven articles were included as a result of the manual search. Adherence measures identified were: self-report (reported in 50 publications), electronic measures (33), pharmacy refills and claims data (26) and pill counts (25). Patient self-report, electronic measures, pharmacy refill and claims data were the most commonly used measures of adherence in research, routine practice, epidemiological and intervention studies. These methods, and their strengths and limitations have been described in this paper. Conclusion A multitude of indirect measures of adherence exist in the literature, however, there is no “gold” standard for measuring adherence to medications. Triangulation of methods increases the validity and reliability of the adherence data collected. To strengthen the adherence data collected and allow for comparison of data, future research and practice interventions should use an internationally accepted, operational standardized definition of medication adherence and clearly describe the medication adherence methods used.


Adherence assessment Electronic monitoring Medication Medication adherence Patient compliance Pharmacy refills Prescription claims database Self-report 


Conflicts of interest





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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2013

Authors and Affiliations

  • Audrey Lehmann
    • 1
    • 2
    • 3
  • Parisa Aslani
    • 4
  • Rana Ahmed
    • 4
  • Jennifer Celio
    • 5
    • 6
  • Aurelie Gauchet
    • 1
    • 7
  • Pierrick Bedouch
    • 1
    • 2
    • 3
  • Olivier Bugnon
    • 5
    • 6
  • Benoît Allenet
    • 1
    • 2
    • 3
  • Marie Paule Schneider
    • 5
    • 6
    • 8
    Email author
  1. 1.Univ. Grenoble-AlpesGrenobleFrance
  2. 2.TIMC-IMAG UMR 5525 / ThemasGrenobleFrance
  3. 3.Pharmacy DepartmentGrenoble University HospitalGrenobleFrance
  4. 4.Faculty of PharmacyThe University of SydneySydneyAustralia
  5. 5.Community Pharmacy, School of Pharmaceutical SciencesUniversity of Geneva, University of LausanneGenevaSwitzerland
  6. 6.Community Pharmacy, Department of Ambulatory Care and Community MedicineUniversity of LausanneLausanneSwitzerland
  7. 7.Inter-University Laboratory of Psychology (LIP)GrenobleFrance
  8. 8.Community pharmacyPharmacie de la Policlinique Médicale UniversitaireLausanneSwitzerland

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