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International Journal of Clinical Pharmacy

, Volume 34, Issue 4, pp 644–650 | Cite as

Budesonide efficacy and safety in patients with bronchiectasis not due to cystic fibrosis

  • Rosana Hernando
  • María Estrella Drobnic
  • María Jesús Cruz
  • Adelaida Ferrer
  • Pilar Suñé
  • J. Bruno MontoroEmail author
  • Ramon Orriols
Research Article

Abstract

Objective The therapeutic benefit of inhaled corticoids in bronchiectasis not due to cystic fibrosis is still not well documented. The aim of the present study was to assess the efficacy and safety of inhaled corticoids in this disease. Setting This study was conducted at a tertiary university hospital in the city of Barcelona, Catalonia, (Spain). Method A prospective, double-blind, parallel, placebo-masked study was conducted. Seventy-seven patients (40 women; mean age: 68 years) were randomly assigned to receive either 400 mcg budesonide twice daily or placebo and were regularly reviewed for six months. Results Differences in forced vital capacity and forced expiratory volume in the first second between the beginning and end of the study were not significantly lower in the budesonide group than in the placebo group, either in absolute values [−17.4 (386.9) versus −21.4 (375.5)] or in percentages [−1.9(9.5) versus −2.8 (11.6)]. Microbiological criteria applied to evaluate changes between the beginning and end of the study showed no worsening in the budesonide group compared with the control group, whereas a non-significant improvement was obtained in 8.1 % of cases in the budesonide group compared to 3 % in the placebo group. Although significance was only achieved for sputum eosinophils (p = 0.021), a consistent tendency towards improvement was also observed in secondary end-points (symptoms, number and duration of exacerbations, quality of life, sputum cytology and interleukin-8) in the budesonide group. Conclusion Although further studies are required, inhaled corticoid treatment may be efficacious and safe in bronchiectasis not due to cystic fibrosis.

Keywords

Bronchiectasis Budesonide Inhaled corticoid 

Notes

Acknowledgments

The authors wish to thank Christine O’Hara for her help with the English translation of the manuscript and Rosa Llòria for editorial assistance.

Funding

This work was supported by the Catalan Foundation of Pneumology (FUCAP) through a grant attributed to RH, MED and RO.

Conflicts of interest

None declared.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Rosana Hernando
    • 1
    • 2
  • María Estrella Drobnic
    • 1
    • 3
  • María Jesús Cruz
    • 1
    • 3
  • Adelaida Ferrer
    • 4
  • Pilar Suñé
    • 5
  • J. Bruno Montoro
    • 5
    Email author
  • Ramon Orriols
    • 1
    • 3
  1. 1.Servei de Pneumologia, Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona, CataloniaSpain
  2. 2.Parc Sanitari St. Joan de DéuBarcelona, CataloniaSpain
  3. 3.CIBER Enfermedades Respiratorias (CIBERES)Barcelona, CataloniaSpain
  4. 4.Servei de Microbiologia, Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona, CataloniaSpain
  5. 5.Servei de Farmàcia, Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona, CataloniaSpain

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