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International Journal of Clinical Pharmacy

, Volume 33, Issue 3, pp 473–474 | Cite as

Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics

  • Karel AllegaertEmail author
Commentary

Abstract

Introduction of the available knowledge on pharmacogenetics very likely is one of the tools to close the gap between ‘population’ focused evidence based and ‘individual’ mechanism based medicine. However, besides pharmacogenetics, other covariates like age, renal function and/or co-medication should also be considered simultaneously when aiming for a ‘tailored’ pharmacotherapy. To illustrate this, we further extended the tramadol example used by Wilffert et al. to illustrate the complex interplay between developmental pharmacology and pharmacogenetics.

Keywords

CYP2D6 Developmental pharmacology Pharmacogenetics Tailored pharmacotherapy Tramadol 

Notes

Acknowledgments

The clinical research of Karel Allegaert is supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical Investigatorship (1800209 N).

References

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    Wilffert B, Swen J, Mulder H, et al. From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics. Pharm World Sci. 2010. doi: 10.1007s/s11096-010-9446-1.
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    Allegaert K, van Schaik RH, Vermeersch S, et al. Postmenstrual age and CYP2D6 polymorphisms determine tramadol O-demethylation in critically ill neonates and infants. Pediatr Res. 2008;63:674–9.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Neonatal Intensive Care Unit, Division of Woman and ChildUniversity Hospitals LeuvenLeuvenBelgium

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