Pharmacy World & Science

, Volume 32, Issue 4, pp 420–423 | Cite as

A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets

  • Virgilijus UlozaEmail author
  • Ingrida Uloziene
  • Egle Gradauskiene
Short Research Report


Objective To explore the swallowing-enhancing and taste-masking effects of MedCoat, a new disposable device used to apply a coating to tablets just before oral administration. Setting Kaunas Medical University Hospital in Lithuania. Method The study was performed as a randomized cross-over study. In total 41 subjects (20 male and 21 female) were enrolled in the study. Subjects were healthy volunteers who at least sometimes experience difficulties swallowing tablets. Subjects were asked to swallow placebo tablets uncoated and coated with MedCoat in a randomized order, and indicate their preferences. Subjects were also asked to evaluate the taste-masking properties of MedCoat. Results Of the 41 subjects, 40 (97.6%) found it less difficult to swallow non-flavoured placebo tablets coated with MedCoat compared to identical uncoated tablets. Forty subjects (97.6%) found it less difficult to swallow divided non-flavoured placebo tablets coated with MedCoat compared to identical uncoated divided tablets. All 41 subjects (100.0%) found it less difficult to swallow bitter flavoured placebo tablets coated with MedCoat compared to identical uncoated tablets. All 41 (100.0%) of the subjects stated that MedCoat completely masked the bitter taste of a bitter flavoured tablet. Conclusion The study showed that MedCoat made tablets easier to swallow for people with difficulties swallowing tablets and that it masked the taste of bitter tasting tablets. MedCoat could therefore be a valuable tool to aid the oral taking of tablets for patients who have difficulties swallowing tablets.


Coating Compliance Oral medication Swallowing Tablets Taste 



The authors would like to acknowledge Martin Ålenius, M.Sc. for statistical assistance.


This study was supported by Med Coat AB, Stockholm, Sweden. Med Coat AB supplied the MedCoat coating but had no role in the study design; nor in the collection, analysis, and interpretation of data; nor in the preparation, review, or approval of the manuscript; nor in the decision to submit the manuscript for publication.

Conflicts of interest

The authors have no conflicts of interest other than the source of funding.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Virgilijus Uloza
    • 1
    Email author
  • Ingrida Uloziene
    • 2
  • Egle Gradauskiene
    • 1
  1. 1.Department OtolaryngologyKaunas University of MedicineKaunasLithuania
  2. 2.Department of Neurosciences, Institute For Biomedical ResearchKaunas University of MedicineKaunasLithuania

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