Drug treatments in a neonatal setting: focus on the off-label use in the first month of life
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Objective The purpose of this work was to analyse drugs prescribed in the first month of life among a group of newborns admitted to the Neonatal Intensive Care Unit and Neonatal Pathology of Cagliari University Hospital. Method This pilot study was prospectively conducted during a 1-month period and involved all newborns admitted to our hospital that received a pharmacotherapy. After obtaining written parental consent, data collected from each newborn included date of birth, sex, gestational age and weight. Also, diagnosis and information about each drug administered during the first month of life: dose, frequency, route of administration, and indication for use was collected. Results Among the 79 newborn infants admitted to our hospital during the study period, 38 received a pharmacotherapy and were enrolled in our study. A total of 88 treatments were given: 41 (47%) followed the terms of the product license, 47 (53%) were used in an unlicensed or off-label manner. Conclusion Our results confirm this trend of drug use in the neonatological field and suggest the need to update information contained in the data sheets of medicines.
KeywordsItaly Medicines Newborn Off-label prescribing
Special thanks to Patrizia Baire for her technical and organisational support.
No external sources of funding for this work were obtained.
Conflicts of interest
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