Pharmacy World & Science

, 32:19 | Cite as

Hyponatremia associated with paroxetine induced by sodium-restricted diet and hypotonic saline

  • Tetsuro KoideEmail author
  • Toru Wakabayashi
  • Toru Matsuda
  • Shinichiro Horiike
  • Keiko Watanabe
Case Report


Case description An 89-year-old woman taking paroxetine was admitted to our hospital for femoral neck fracture; her diet became sodium restricted due to hypertension. After admission, the femoral head replacement was performed and hypotonic saline was administered over 2 days. On the fifth day after the operation, severe hyponatremia was observed and treated with oral fluid restriction, furosemide, sodium chloride and paroxetine discontinuance. In a few days, serum sodium concentration returned to baseline level. Conclusions Besides risk factors for SIADH, a sodium-restricted diet and infusions of hypotonic saline in the perioperative period should be considered risk factors for SIADH associated with paroxetine.


Hyponatremia Hypotonic saline Paroxetine Sodium-restricted diet 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Tetsuro Koide
    • 1
    Email author
  • Toru Wakabayashi
    • 2
  • Toru Matsuda
    • 2
  • Shinichiro Horiike
    • 3
  • Keiko Watanabe
    • 1
  1. 1.Department of PharmacyKuwana Municipal HospitalKuwanaJapan
  2. 2.Department of OrthopedicsKuwana Municipal HospitalKuwanaJapan
  3. 3.Department of Internal MedicineKuwana Municipal HospitalKuwanaJapan

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