Pharmacy World & Science

, Volume 31, Issue 2, pp 238–240 | Cite as

Two acute psychotic episodes after administration of bupropion: a case of involuntary rechallenge

  • Hervé JavelotEmail author
  • Alexandre Baratta
  • Luisa Weiner
  • Thierry Javelot
  • Cathy Nonnenmacher
  • Jean-Frédéric Westphal
  • Michaël Messaoudi
Case Report


Bupropion is an antidepressant drug also used as a smoking cessation aid, which inhibits norepinephrine and dopamine re-uptake. Given its pharmacological properties, it has been associated with reports on psychosis and acute delirious episodes. Case We report the case of a patient with schizoaffective disorder who developed two psychotic episodes respectively after a four and a two-day administration of sustained-release (SR) bupropion at a dose of 150 mg/day. To our knowledge, this is the first reported case of involuntary rechallenge with bupropion SR during a smoking cessation program. Conclusion There is a serious risk of incorrectly identifying bupropion as only a therapy for nicotine withdrawal without taking the precaution of exploring possible psychiatric co-morbidity with addiction. Our case illustrates the problem.


Acute psychosis Adverse drug reaction Bupropion Rechallenge Side effects 



The authors want to express their gratitude to the translators, Mr Jean-Yves Bart and Mr Jesse David Tatum, for revising the text.

Conflicts of interest

All the authors of this article attest that there was no potential conflict of interest that could have influenced this work.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Hervé Javelot
    • 1
    Email author
  • Alexandre Baratta
    • 3
  • Luisa Weiner
    • 4
  • Thierry Javelot
    • 2
  • Cathy Nonnenmacher
    • 1
  • Jean-Frédéric Westphal
    • 4
  • Michaël Messaoudi
    • 5
  1. 1.Secteur PharmacieEtablissement Public Santé Alsace Nord (EPSAN)BrumathFrance
  2. 2.Secteur 38G11Centre Psychothérapique du VionSaint Clair de La TourFrance
  3. 3.Secteur G06Etablissement Public Santé Alsace Nord (EPSAN)67170BrumathFrance
  4. 4.Secteur G03Etablissement Public Santé Alsace Nord (EPSAN)BrumathFrance
  5. 5.Neuropsychopharmacology DepartmentETAP Research CentreVandoeuvre-les-NancyFrance

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