Advertisement

Pharmacy World & Science

, Volume 30, Issue 4, pp 316–318 | Cite as

Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report

  • Tiene G. M. BautersEmail author
  • Joris Verlooy
  • Hugo Robays
  • Geneviéve Laureys
Case Report

Abstract

We present a case of severe mucositis due to a drug–drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.

Keywords

Drug-drug interaction Leukemia Methotrexate Omeprazole Pediatric oncology 

Notes

Conflicts of interest

There are no conflicts of interest nor funding.

References

  1. 1.
    Micromedex, Health Care Series. Thomson Health Care, Greenwood Village, Colorado, USA, 2007.Google Scholar
  2. 2.
    Peyriere H, Cociglio M, Margueritte G, Vallat C, Blayac JP, Hillaire-Buys D. Optimal management of methotrexate intoxication in a child with osteosarcoma. Ann Pharmacother. 2004;38:422–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Tortajada-Ituren J, Ordovas-Baines J, Llopis-Salvia P, Jimenez-Torres N. High-dose methotrexate-doxycycline interaction. Ann Pharmacother. 1999;33:804–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Lam M, Ignoffo R. A guide to clinically relevant drug interactions in oncology. J Oncol Pharm Pract. 2003;9:45. doi: 10.1191/1078155203jp107oa.CrossRefGoogle Scholar
  5. 5.
  6. 6.
    EsPhALL: European Intergroup Study on post-induction treatment of PhALL (Phase II/III study).Google Scholar
  7. 7.
    Beorlegui B, Aldaz A, Ortega A, Aquerreta I, Sierrasesumega L, Giraldez J. Potential interaction between methotrexate and omeprazole. Ann Pharmacother. 2000;34:1024–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Reid T, Yuen A, Catolico M, et al. Impact of omeprazole on the plasma clearance of methotrexate. Cancer Chemother Pharmacol. 1993;33:82–4.PubMedCrossRefGoogle Scholar
  9. 9.
    Whelan J, Hoare D, Leonard P. Omeprazole does not alter plasma methotrexate clearance. Cancer Chemoter Pharmacol. 1999;44:88–9.CrossRefGoogle Scholar
  10. 10.

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Tiene G. M. Bauters
    • 1
    Email author
  • Joris Verlooy
    • 2
  • Hugo Robays
    • 1
  • Geneviéve Laureys
    • 2
  1. 1.Department of PharmacyGhent University HospitalGhentBelgium
  2. 2.Department of Paediatric Hemato-OncologyGhent University HospitalGhentBelgium

Personalised recommendations