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Particle Image Velocimetry Evaluation of Fluid Flow Profiles in USP 4 Flow-Through Dissolution Cells

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ABSTRACT

Purpose

To evaluate fluid flow profiles in the flow-through cell (FTC, USP apparatus 4) system with pulsatile and non-pulsatile pumps.

Methods

Instantaneous velocity vectors in the dissolution cells were obtained from images sequentially captured by a particle image velocimetry (PIV) system. The data were sorted to follow the pump pulse cycle.

Results

The analysis showed changes in the flow profiles during a pump pulse (0.5 s) at a 0.025-s interval in two sizes of cells installed in the FTC system. Supplying a slow flow from the pulsatile pump induced instantaneous downward (inner layer) and upward (outer layer) flow in the larger cell during the suction phase. Analysis at varied medium and cell temperatures strongly suggested a contribution of natural convection to the complex flow caused by relatively high cell temperature. Uniform upward flow was observed in other cells and flow rate conditions. The time-averaged vertical velocities in the cells were similar in the pulsatile and non-pulsatile pump systems.

Conclusions

The PIV analysis provides information on how flow rate and pump pulse affect fluid flow profiles at multiple points in flow-through dissolution cells. An appropriate temperature control should reduce the complex flow of the medium in the FTC system.

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Abbreviations

CFD:

Computational fluid dynamics

EP:

European Pharmacopoeia

FTC:

Flow-through cell

i.d:

Inside diameter

JP:

Japanese Pharmacopoeia

MRI:

Magnetic resonance imaging

PIV:

Particle imaging velocimetry

P-Tp :

Processing phase time

Tp :

Time phase of pump

USP:

United States Pharmacopeia

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ACKNOWLEDGMENTS AND DISCLOSURES

This work is partly supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour, and Welfare of Japan.

Author information

Correspondence to Hiroyuki Yoshida.

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Yoshida, H., Kuwana, A., Shibata, H. et al. Particle Image Velocimetry Evaluation of Fluid Flow Profiles in USP 4 Flow-Through Dissolution Cells. Pharm Res 32, 2950–2959 (2015) doi:10.1007/s11095-015-1676-4

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KEY WORDS

  • dissolution testing
  • flow-through cell system
  • hydrodynamics
  • particle image velocimetry
  • pulsatile pump