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Pharmaceutical Chemistry Journal

, Volume 52, Issue 10, pp 855–859 | Cite as

Binding Constants of Maackia Amurensis Whole Extract and its Separate Flavanoids to Estradiol Receptors

  • E. N. Kareva
  • D. A. Tikhonov
  • S. E. Mironov
  • S. A. Fedoreev
  • N. I. Kulesh
  • N. L. Shimanovskii
Article
  • 9 Downloads

Extract of Maackia amurensis containing genistein and resveratrol demonstrated competitive specific binding to estradiol receptors with more affinity for ERβ (average RBA = 6.25%) than for ERα (average RBA = 0.67%) in tests with experimental animals and clinical materials (endometrium biopsy). Associated flavonoids in the extract bound insignificantly to ERs although they could have a potentiating effect in the whole extract. Therefore, M. amurensis extract contained various phytoestrogens that determined the therapeutic potential (effect on cell growth, inflammation, apoptosis, angiogenesis, carbohydrate and lipid metabolism).

Keywords

Maackia amurensis extract radioligand analysis estradiol receptors flavonoids phytoestrogens 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. N. Kareva
    • 1
    • 2
  • D. A. Tikhonov
    • 2
  • S. E. Mironov
    • 2
  • S. A. Fedoreev
    • 3
  • N. I. Kulesh
    • 3
  • N. L. Shimanovskii
    • 1
  1. 1.N. I. Pirogov Russian National Research Medical UniversityMoscowRussia
  2. 2.I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RFMoscowRussia
  3. 3.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern BranchRussian Academy of SciencesVladivostokRussia

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