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Pharmaceutical Chemistry Journal

, Volume 53, Issue 8, pp 701–705 | Cite as

Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

  • V. L. Gein
  • N. N. KasimovaEmail author
  • S. V. Chashchina
  • A. V. Starkova
  • B. Ya. Syropyatov
Article
  • 11 Downloads

A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.

Keywords

4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-3-pyrrolin-2-ones pyrrolo[3 4-c]pyrazole synthesis anti-inflammatory activity analgesic activity hemostatic effect 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. L. Gein
    • 1
  • N. N. Kasimova
    • 1
    Email author
  • S. V. Chashchina
    • 1
  • A. V. Starkova
    • 1
  • B. Ya. Syropyatov
    • 1
  1. 1.Perm State Pharmaceutical AcademyMinistry of Health of the RFPermRussia

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