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Pharmaceutical Chemistry Journal

, Volume 53, Issue 6, pp 553–558 | Cite as

Composition and Biological Activity of Furanoquinolizidine Alkaloids from Yellow Water-Lily (Nuphar Lutea L. Smith) Rhizomes

  • V. I. Sheichenko
  • O. N. Tolkachev
  • V. I. Osipov
  • O. P. Sheichenko
  • V. V. Anufrieva
  • V. A. TimoshinaEmail author
  • T. V. Fateeva
  • V. V. Bortnikova
  • V. A. Bykov
Article
  • 13 Downloads

A method for producing pharmaceutical drug substance from Nuphar lutea L. Smith that used orthophosphoric acid instead of the chlorinated solvent dichloroethane (DCE), which was used previously to produce lutenurine preparation, was developed. Furanoquinolizidine alkaloid salts containing immonium ions were shown to dominate lutenurine drug substances prepared by both technologies. NMR methods were used to establish the identity of the substance and to determine it quantitatively. The UV absorption maximum at 293 nm was characteristic of all alkaloids with immonium ions (S–CH=N+). The antimicrobial activity, toxicity, and physicochemical characteristics of substances prepared by the two different technologies were practically identical.

Keywords

lutenurine furanoquinolizidine alkaloids (FQAs) yellow water lily Nuphar lutea nuphleine nuphleine bis-anhydrodichloride HPLC ultra-high performance liquid chromatography (UPLC) mass and NMR spectra 

Notes

Acknowledgments

The work was performed in the framework of VILAR research and development topic No. AAAA-A-17- 117080910128-0, “Scientific formation, storage, and study of a different type of gene pool biocollection to design new drugs.”

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. I. Sheichenko
    • 1
  • O. N. Tolkachev
    • 1
  • V. I. Osipov
    • 1
  • O. P. Sheichenko
    • 1
  • V. V. Anufrieva
    • 1
  • V. A. Timoshina
    • 1
    Email author
  • T. V. Fateeva
    • 1
  • V. V. Bortnikova
    • 1
  • V. A. Bykov
    • 1
  1. 1.All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR)Russian Academy of Agricultural SciencesMoscowRussia

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