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Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 483–486 | Cite as

Application of Near-IR Spectroscopy to Analysis of Kemantane Drug Substance

  • A. V. Tolkacheva
  • K. S. Balyklova
  • L. N. Grushevskaya
  • N. I. Avdyunina
  • B. M. Pyatin
  • V. I. Prokof’eva
  • S. V. Chernova
  • L. M. GaevayaEmail author
  • M. S. Sergeeva
Article
  • 5 Downloads

Near-IR spectroscopy is a promising analytical method in pharmacy. It was shown that it can be used as a rapid method for confirming the identity and analyzing the purity of kemantane (5-hydroxyadamantan-2-one) drug substance.

Keywords

near-IR spectroscopy NIR discriminant analysis kemantane (5-hydroxyadamantan-2-one) rapid analysis 

References

  1. 1.
    European Pharmacopoeia 8.0, 2.2.40 Near-infrared spectroscopy, 2014.Google Scholar
  2. 2.
    US Pharmacopeia 37, National Formulary 32, Near-infrared spectrophotometry, 2014.Google Scholar
  3. 3.
    Supplement II to the Japanese Pharmacopoeia, XVth Ed., p. 2284, Near Infrared Spectrometry, 2009.Google Scholar
  4. 4.
    State Pharmacopoeia of the Russian Federation [in Russian], XIIIth Ed., Vol. 1, GPM. 1.2.1.1.0001.15, 2015.Google Scholar
  5. 5.
    W. Schmidt, Optical Spectroscopy in Chemistry and Life Sciences, Wiley-VCH, Weinheim, 2005 [Russian translation, Tekhnosfera, Moscow, 2007].Google Scholar
  6. 6.
    N. G. Artsimovich, T. A. Fedeeva, T. S. Galushina, et al., Immunologiya, No. 6, 21 – 23 (1990).Google Scholar
  7. 7.
    I. S. Morozov, V. I. Petrov, and S. A. Sergeeva, Pharmacology of Adamantanes [in Russian], Volgogradskaya Meditsinskaya Akademiya, Volgograd, 2001.Google Scholar
  8. 8.
    N. V. Klimova, N. I. Avdyunina, et al., RU Pat. No. 2,104,994, Feb. 20, 1998; Byull. Izobret., No. 5 (1998).Google Scholar
  9. 9.
    A. V. Tolkacheva, L. N. Grushevskaya, N. I. Avdyunina, et al., Khim.-farm. Zh., 47(6), 44 – 50 (2013); Pharm. Chem. J., 47(6), 330 – 336 (2013).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. V. Tolkacheva
    • 1
    • 2
  • K. S. Balyklova
    • 2
  • L. N. Grushevskaya
    • 1
  • N. I. Avdyunina
    • 1
  • B. M. Pyatin
    • 1
  • V. I. Prokof’eva
    • 2
  • S. V. Chernova
    • 2
  • L. M. Gaevaya
    • 1
    Email author
  • M. S. Sergeeva
    • 1
  1. 1.V. V. Zakusov State Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.I. M. Sechenov First Moscow State Medical UniversityMinistry of Health of Russia (Sechenov University)MoscowRussia

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