Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 467–471 | Cite as

Modeling the Desorption Stage in Lyophilization Technology of bis(N-Monosuccinyl-L-Glutamyl-L-Lysine) Hexamethylenediamide (GK-2)

  • E. V. Blynskaya
  • S. V. TishkovEmail author
  • K. V. Alekseev
  • S. V. Minaev

Modeling lyophilization is the most convenient approach to optimizing the drying stage because it allows the optimal temperature regime for secondary drying to be selected using a small number of experiments and the duration of the process to be calculated as a function of the conditions. A simple mixed mathematical model of the process was used because of the ability to extrapolate the data and the small number of required experiments. The dependences of the drying rate on thermal variables at a constant total pressure and of the possibility of a dynamic temperature rise on residual moisture content were calculated. The optimal secondary drying regime was determined by comparing the performance of various regimes, verifying the reproducibility of the model, and comparing theoretical and experimental values of residual moisture. The most suitable drying regime for bis(N-monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) lyophilizates for injection was selected.


drying regime optimization secondary drying lyophilization GK-2 


  1. 1.
    E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev, et al., Farmatsiya, 66(1), 14 – 18 (2017).Google Scholar
  2. 2.
    E. V. Blynskaya, S. V. Tishkov, and K. V. Alekseev, Ross. Bioterapevticheskii Zh., 16(1), 6 – 11 (2017).Google Scholar
  3. 3.
    E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev, and S. V. Minaev, Ross. Bioterapevticheskii Zh., 17(2), 15 – 21 (2018).Google Scholar
  4. 4.
    P. Yu. Povarnina, O. N. Vorontsova, T. A. Gudasheva, et al., Acta Nat. (Russ. Ed.), 5(3), 88 – 95 (2013).Google Scholar
  5. 5.
    R. Pisano, D. Fissore, and A. A. Barresi, Drying Technol., 30(11 – 12), 1307 – 1316 (2012).CrossRefGoogle Scholar
  6. 6.
    B. C. Hancock and G. Zografi, Pharm. Res., 11(4), 471 – 477 (1994).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Blynskaya
    • 1
  • S. V. Tishkov
    • 1
    Email author
  • K. V. Alekseev
    • 1
  • S. V. Minaev
    • 1
  1. 1.V. V. Zakusov State Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia

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