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Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 462–466 | Cite as

Syntheses of Melanotan II and YSL Amide by Ajiphase® Methodology

  • T. A. Sanguliya
  • A. O. Antipova
  • S. V. Shkavrov
  • N. B. ÉpshteinEmail author
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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The promising antitumor peptides Melanotan II and YSL amide were synthesized for the first time in gram quantities in overall yields of 72 and 50%, respectively, by Ajiphase® methodology. This method was shown to be promising for peptide manufacturing. The proposed methods are as convenient as polymer-phase syntheses with the reagent consumption and associated analytical simplicity of classical solution syntheses.

Keywords

peptide synthesis Melanotan II YSL amide Ajiphase® methodology Fmoc strategy 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • T. A. Sanguliya
    • 1
  • A. O. Antipova
    • 1
  • S. V. Shkavrov
    • 1
  • N. B. Épshtein
    • 1
    Email author
  1. 1.National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)MoscowRussia

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