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Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 458–461 | Cite as

Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice

  • E. N. AmosovaEmail author
  • I. V. Shilova
  • E. P. Zueva
  • O. Yu. Rybalkina
Article
  • 14 Downloads

Meadowsweet extract was prepared by heating the aerial part of Filipendula ulmaria (L.) Maxim. in EtOH (70%). Experiments in C57BL/6 mice with Lewis lung carcinoma (LLC) showed that the extract at doses of 50 and 100 mg/kg exhibited dose-dependent antimetastatic action. Combined treatment of animals with LLC using cyclophosphamide and meadowsweet extract at doses of 50 and 100 mg/kg increased the antitumor effect of the cytostatic drug.

Keywords

Filipendula ulmaria (L.) Maxim. extract Lewis lung carcinoma cytostatic therapy 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. N. Amosova
    • 1
    Email author
  • I. V. Shilova
    • 1
  • E. P. Zueva
    • 1
  • O. Yu. Rybalkina
    • 1
  1. 1.E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

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