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Pharmaceutical Chemistry Journal

, Volume 53, Issue 5, pp 436–439 | Cite as

Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids

  • R. E. KhomaEmail author
  • V. O. Gelmboldt
  • A. A. Énnan
  • T. L. Gridina
  • A. S. Fedchuk
  • V. P. Lozitsky
  • I. M. Rakipov
  • A. S. Vladyka
Article
  • 7 Downloads

Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture.

Keywords

aminomethanesulfonic acids antioxidant activity anti-influenza activity A/Hong Kong/1/68 (H3N2) A/PR/8/34 (H1N1) 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • R. E. Khoma
    • 1
    • 2
    Email author
  • V. O. Gelmboldt
    • 2
  • A. A. Énnan
    • 1
  • T. L. Gridina
    • 3
    • 1
  • A. S. Fedchuk
    • 4
    • 1
  • V. P. Lozitsky
    • 4
  • I. M. Rakipov
    • 5
  • A. S. Vladyka
    • 3
  1. 1.Physical-Chemical Institute for Environmental and Human ProtectionMinistry of Education and Science and National Academy of Sciences of UkraineOdessaUkraine
  2. 2.I. I. Mechnikov Odessa National UniversityOdessaUkraine
  3. 3.Odessa National Medical UniversityOdessaUkraine
  4. 4.Odessa Research Center Biomedical Testing of Food and DrugsOdessaUkraine
  5. 5.A. V. Bogatsky Physical-Chemical InstituteNational Academy of Sciences of UkraineOdessaUkraine

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